|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The initial study showing linkage of the P50 deficit to the chromosome 15q14 locus of the alpha 7-nicotinic acetylcholine receptor is an example of the potential usefulness of these phenotypes for combined genetic and neurobiological study of schizophrenia.
|
10394470 |
1999 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In persons with bipolar type schizoaffective disorder, CHRNA7 promoter region allelic variants are linked to the capacity to inhibit the P50 auditory evoked potential and thus are associated with a type of illness genetically and biologically more similar to schizophrenia.
|
17192894 |
2007 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have suggested that the alpha-7-nicotinic receptor D15S1360 polymorphism is associated with schizophrenia and a deficiency in the normal inhibition of the P50 auditory-evoked response.
|
15100704 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deficits in gating of the P50 response have been shown to segregate with schizophrenia in this sample and may identify carriers of gene(s) predisposing for schizophrenia.
|
8094267 |
1993 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Diminished gating of the P50 auditory evoked response to repeated stimuli is a psychophysiological feature of schizophrenia, that is also present in many relatives of patients.
|
1450287 |
1992 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia.
|
23598060 |
2013 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PERG results showed a significant increase of the P50 implicit time in schizophrenia patients compared with controls (t(55) = 2.1, p < .05, d = 0.55) and a significant increase of the N95 implicit time in schizophrenia patients compared with controls (t(55) = 4.2; p < .001, d = 0.66).
|
31353068 |
2019 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A 2bp deletion in exon 6 of CHRFAM7A, which disrupts the hybrid gene and has previously been associated with P50 deficit, was genotyped in 251 individuals from the Maudsley Family Study of schizophrenia.
|
17012698 |
2006 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with schizophrenia and half their first-degree relatives have deficits in sensory gating, with P50 ratios that are generally greater than 50%.
|
15465979 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Abnormality in the P50 auditory-evoked potential gating is an endophenotype associated with schizophrenia.
|
12399955 |
2002 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A CHRNA7 genotype associated with schizophrenia was correlated with diminished P50 inhibition in the placebo-treated infants, but not in the choline-treated infants.
|
23318559 |
2013 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three electrophysiological endophenotypes are routinely studied in schizophrenia (SCZ): smooth pursuit eye movement (SPEM) dysfunction, deficits in P50 auditory-evoked potential inhibition, and saccadic inhibition deficits.
|
27825784 |
2016 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the core promoter of the gene are associated with schizophrenia and also with diminished inhibition of the P50 response.
|
12685995 |
2003 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diminished suppression of the P50 auditory evoked potential is a phenotype used in studies of genetic susceptibility in schizophrenia.
|
15625200 |
2005 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gating of the theta-alpha-frequency oscillatory signal in the paired-click paradigm is more strongly associated with schizophrenia and has significantly higher heritability compared with the traditional P50 gating.
|
18762587 |
2008 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
PPI and P50 gating measures demonstrate substantially increased heritability in schizophrenia families with a higher genetic vulnerability for illness, providing further support for the commonality of genes underlying both schizophrenia and gating measures.
|
26441157 |
2016 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that P50 auditory evoked potentials can be recorded across multiple sites and reliably demonstrate a physiological abnormality in schizophrenia.
|
20382002 |
2010 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings provide insight into the mechanisms of P50 suppression in schizophrenia and could potentially improve the performance of early identification and diagnosis of schizophrenia for the earliest intervention.
|
31803031 |
2019 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present findings suggest that COMT Val(108/158)Met polymorphism may not contribute to the risk of schizophrenia and to the P50 deficits, but may contribute to the negative symptoms of schizophrenia among Han Chinese.
|
27315458 |
2016 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The alpha7 nicotinic acetylcholine receptor gene (CHRNA7) is located at 15q13-q14 in a region that is strongly linked to the P50 sensory gating deficit, an endophenotype of schizophrenia and bipolar disorder.
|
18545269 |
2008 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A deficit in sensory gating measured by the suppression of P50 auditory event-related potential (ERP) has been implicated in the biological bases of schizophrenia and some other psychiatric disorders and proposed as a candidate endophenotype for genetic studies.
|
17014995 |
2007 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intriguingly, we observed a significant positive association between ADORA2A upregulation and baseline P50 amplitudes in the schizophrenia group.
|
22705363 |
2012 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to the Colorado studies in the non-Colorado studies P50 suppression would not qualify as an endophenotype for schizophrenia.
|
17604606 |
2007 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit.
|
30974230 |
2019 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
All four event-related potential indices are potentially valid endophenotypes for schizophrenia, but P50 suppression and P300 amplitude show the closest genetic relationship to schizophrenia.
|
17475740 |
2007 |