|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
There is an association between a genetic polymorphism in the ZNF259 gene involved in lipid metabolism and coronary artery disease.
|
30902787 |
2019 |
|
Coronary Artery Disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Also subjects who carried the G allele of the ZNF259 polymorphism were at an increased the risk of developing CAD [OR 1.86, 95% CI: 1.06-3.25, p value = 0.029] and had an increased TC, LDL and TG levels (p < 0.05).
|
30902787 |
2019 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Impact of gender and age on the association of the BUD13-ZNF259 rs964184 polymorphism with coronary heart disease.
|
29339699 |
2018 |
|
Coronary Artery Disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Impact of gender and age on the association of the BUD13-ZNF259 rs964184 polymorphism with coronary heart disease.
|
29339699 |
2018 |
|
Coronary Artery Disease
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Coronary Artery Disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Interaction of variants that belong to regulatory genes BUD13 and ZPR1 with APOA5-APOA4 intergenic variants is also observed to significantly increase the risk towards CAD.
|
27257688 |
2016 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.
|
26397108 |
2015 |
|
Coronary Artery Disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.
|
26397108 |
2015 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
MG 18∶2 showed an enrichment (P-value = 0.002) of significant associations with CHD-associated SNPs (P-value = 1.2×10-7 for association with rs964184 in the ZNF259/APOA5 region) and a weak, but positive causal effect (odds ratio = 1.05 per SD increment in MG 18∶2, P-value = 0.05) on CHD, as suggested by Mendelian randomization analysis.
|
25502724 |
2014 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary heart disease
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Four genetic variants (APOA5_rs651821, EFCAB4B_rs4766165, ZNF259_rs2160669 and APOBEC1_rs10845640) were selected because they increased MetS risk after adjusting for covariates.
|
31544728 |
2019 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population.
|
30382898 |
2018 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes.
|
27827461 |
2016 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
We have identified the novel APOA5-ZNF259 haplotype manifesting sex-dependent effects on elevation of the TG:HDL-C ratio as well as the increased risk for MS.
|
24618354 |
2014 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
22399527 |
2012 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
22399527 |
2012 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
|
Metabolic Syndrome X
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
|
Hypertriglyceridemia
|
0.120 |
GeneticVariation
|
phenotype |
GWASCAT |
A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia.
|
27599772 |
2017 |
|
Hypertriglyceridemia
|
0.120 |
GeneticVariation
|
phenotype |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, gender and body mass index revealed that rs964184 of ZPR1 (P=5.1x10‑7; odds ratio, 1.37; dominant model), rs4845625 of IL6R (P=0.0019, odds ratio, 1.25; dominant model) and rs46522 of UBE2Z (P=0.0039, odds ratio, 1.19; dominant model) were significantly associated with hypertriglyceridemia, and that rs599839 of PSRC1 (P=0.0004, odds ratio, 0.70; dominant model) and rs2075650 of TOMM40 (P=0.0004, odds ratio, 1.43; dominant model) were significantly associated with hyper‑LDL‑cholesterolemia.
|
26238946 |
2015 |
|
Hypertriglyceridemia
|
0.120 |
GeneticVariation
|
phenotype |
BEFREE |
Our objectives were to determine the association of the BUD13/ZNF259 SNPs and their haplotypes with hypercholesterolaemia (HCH)/hypertriglyceridaemia (HTG) and to identify the possible gene-gene interactions among these SNPs.
|
24780069 |
2014 |