|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic and pharmacological suppression of the ISR, by inhibiting the ISR-inducing double-stranded RNA-activated protein kinase or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, reversed the changes in translation and inhibitory synaptic transmission and rescued the synaptic plasticity and long-term memory deficits in DS mice.
|
31727829 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Genetic and pharmacological suppression of the ISR, by inhibiting the ISR-inducing double-stranded RNA-activated protein kinase or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, reversed the changes in translation and inhibitory synaptic transmission and rescued the synaptic plasticity and long-term memory deficits in DS mice.
|
31727829 |
2019 |
|
Complete Trisomy 21 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic and pharmacological suppression of the ISR, by inhibiting the ISR-inducing double-stranded RNA-activated protein kinase or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, reversed the changes in translation and inhibitory synaptic transmission and rescued the synaptic plasticity and long-term memory deficits in DS mice.
|
31727829 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.
|
29624814 |
2018 |
|
Cognition Disorders
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
ISRIB, a drug-like eIF2B activator, reverses the effects of eIF2 phosphorylation, and in rodents it enhances cognition and corrects cognitive deficits after brain injury.
|
29599213 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bioinformatics analyses reveal that compared to control samples, the immunoproteomic IgG profiling of CRC samples is mainly associated with cell death, survival, and proliferation pathways, especially proteins involved in EIF2 and mTOR signaling.
|
29505855 |
2018 |
|
Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ANA-negative sera from the Scleroderma Family Registry and DNA Repository underwent indirect immunofluorescence, radiolabelled protein immunoprecipitation (± immunodepletion) to identify anti-eIF2B and other CTD-related autoantibodies.
|
29294089 |
2018 |
|
Leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of the Antigenic and Prophylactic Properties of the <i>Leishmania</i> Translation Initiation Factors eIF2 and eIF2B in Natural and Experimental Leishmaniasis.
|
29675401 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Primitive acute myeloid leukemia (AML) cells also display eIF2 scarcity and ISR activity marks leukemia stem cells (LSCs) in primary AML samples.
|
30380403 |
2018 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
EIF2B5 is a subunit of EIF2B that regulates the initiation and the rate of translation and participates in several diseases including tumors.
|
30538549 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice.
|
29899429 |
2018 |
|
Systemic Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ANA-negative sera from the Scleroderma Family Registry and DNA Repository underwent indirect immunofluorescence, radiolabelled protein immunoprecipitation (± immunodepletion) to identify anti-eIF2B and other CTD-related autoantibodies.
|
29294089 |
2018 |
|
Chagas Disease
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
To evaluate if these agents have potential to inhibit trypanosome multiplication by also affecting the phosphorylation of eIF2 alpha subunit (eIF2α), we tested 25 analogs of 1,3-diarylureas and cHAUs against Trypanosoma cruzi, the agent of Chagas disease.
|
29559670 |
2018 |
|
Lung Diseases, Interstitial
|
0.010 |
Biomarker
|
group |
BEFREE |
Cytoplasmic autoantibodies (in otherwise ANA-negative sera) targeting eukaryotic initiation factor-2B (anti-eIF2B) have recently been identified in SSc with clinical associations to dcSSc disease and interstitial lung disease (ILD), although the majority of samples originated from a tertiary SSc-ILD centre.
|
29294089 |
2018 |
|
Iron deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
The regulation of transcription and translation factors in reponse to eIF2 phosphorylation may explain the large overall response to iron deficiency in erythroblasts.
|
29634759 |
2018 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we reported that the expression of casein kinase 2 (CK2) was significantly reduced in brains of middle cerebral artery occlusion/reperfusion (MACO/R) model rats and oxygen-glucose deprivation/reperfusion (OGD/R) model neurons, which was associated with the activation of eIF2-ATF4-CHOP signaling pathway, leading to neuronal apoptosis.
|
29337146 |
2018 |
|
Diffuse Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cytoplasmic autoantibodies (in otherwise ANA-negative sera) targeting eukaryotic initiation factor-2B (anti-eIF2B) have recently been identified in SSc with clinical associations to dcSSc disease and interstitial lung disease (ILD), although the majority of samples originated from a tertiary SSc-ILD centre.
|
29294089 |
2018 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since we show that inhibition of eIF2B also drives neural crest migration and yeast invasiveness, our results suggest that translation reprogramming, an evolutionarily conserved starvation response, has been hijacked by microenvironmental stress signals in melanoma to drive phenotypic plasticity and invasion and determine therapeutic outcome.
|
28096186 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Since we show that inhibition of eIF2B also drives neural crest migration and yeast invasiveness, our results suggest that translation reprogramming, an evolutionarily conserved starvation response, has been hijacked by microenvironmental stress signals in melanoma to drive phenotypic plasticity and invasion and determine therapeutic outcome.
|
28096186 |
2017 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was a global downregulation of the eIF2 pathway and its associated genes in all symptomatic FAP patients.
|
27570551 |
2016 |
|
AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was a global downregulation of the eIF2 pathway and its associated genes in all symptomatic FAP patients.
|
27570551 |
2016 |
|
Liver Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eukaryotic protein translation and recycling of eIF2:GDP related SNP variants were associated with ballooning, steatohepatitis and cirrhosis.
|
23894275 |
2013 |
|
Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eukaryotic protein translation and recycling of eIF2:GDP related SNP variants were associated with ballooning, steatohepatitis and cirrhosis.
|
23894275 |
2013 |
|
Steatohepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eukaryotic protein translation and recycling of eIF2:GDP related SNP variants were associated with ballooning, steatohepatitis and cirrhosis.
|
23894275 |
2013 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pathways such as Recycling of eIF2:GDP, biosynthesis of steroids, Terpenoid biosynthesis and Cholesterol biosynthesis were found to be significantly associated with NASH.
|
23894275 |
2013 |