|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, restoration of CCNB1 expression attenuated the tumor‑suppressive effects of miR‑718 overexpression in NSCLC cells.
|
31746372 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance.
|
30481564 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistology showed overexpression of cyclin B1 protein in tumors compared to surrounding normal tissue and localization in the cytoplasm rather than the nucleus.
|
12009577 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevation of cyclin B1, active cdc2, and HuR in cervical neoplasia with human papillomavirus type 18 infection.
|
16458113 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, control HeLa cells were progressively growing, whereas the tumor growth of HeLa cells pre-treated with cyclin B1 siRNA was strongly inhibited in nude mice, indicating that cyclin B1 is indispensable for tumor growth in vivo.
|
19113992 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the protein level of hnRNPR in the tumor was positively correlated with the expression of CCNB1 and CENPF in clinical samples.
|
31527303 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Secondly, these PEF protocols were evaluated for the delivery of specific siRNAs targeting the cyclin B1 in subcutaneous tumors in mice.
|
31715364 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cyclin B1 levels were significantly overexpressed in poorly differentiated tumors while Cox2 levels were significantly overexpressed in neuroendocrinal tumors.
|
22348039 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated levels of CDK1Tyr15, pCDK1Thr161, Cyclin B1 (total) and pCyclin B1Ser126 were correlated with advanced tumor behaviors and aggressive features.
|
25849598 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As to TMN stage, there is no association with the level of Hsp90α, However, cyclin B1 expression is significantly related to tumor status (p=0.002).
|
24817950 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrate that Pep-3-mediated delivery of antisense-cyclin B1-charged-PNA blocks tumour growth in vivo upon intratumoral and intravenous injection.
|
17341467 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cyclin A1 and cyclin B1 are overexpressed in various tumors but are present at low levels in normal tissues.
|
16984381 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors.
|
26125663 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, we found significant upregulation of CCNB1 and MKI67 in recurrent tumors in comparison with primary tumors of benign meningiomas (P<0.05).
|
22137483 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, qRT-PCR verification suggested that the expression of CCNB1 and CDC6 in breast cancer cells was significantly downregulated in response to APS, while expression of the tumor suppressor gene P53 was significantly increased.
|
31157164 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with ≥1 positive tumor area had significantly increased risk of disease recurrence in univariable analysis compared with patients where all tumor areas were negative for cytoplasmic BUB3 (hazard ratio [HR] = 2.18, 95% confidence interval [CI] 1.41-3.36), CCNB1 (HR = 2.98, 95% CI 1.93-4.61) and PTTG1 (HR = 1.91, 95% CI 1.23-2.97).
|
31801961 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sequencing genomic DNA and cDNA corresponding to P1-P6 region showed that differences in COOH-terminal residues were not due to either DNA mutations or errors in transcription, suggesting a high error rate in translation of cyclin B1 protein in tumors.
|
11696596 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results confirm an essential role for the cdk1/CCNB1 complex in tumor cell survival.
|
26029996 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ectopic delivery of circ-Ccnb1 inhibited tumor growth and extended mouse viability.
|
29795334 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, ectopic delivery of circ-Ccnb1 inhibited tumor growth and extended mouse viability.
|
31199987 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These p53(-/-) mice spontaneously develop cyclin B1(+) tumors.
|
19769738 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In tumour samples, as compared to normal lung tissue, the up-regulated genes included such known tumour markers as CCNB1, PLK, tenascin, KRT8, KRT19 and TOP2A.
|
12173052 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conversely, cyclin B1-specific small interfering RNAs have been shown to dramatically reduce tumor proliferation.
|
25982682 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An in vivo study showed that EVO significantly reduced the growth of gliomas elicited by the subcutaneous injection of U87 cells with increases in cyclin B1, p53, and p-p53 protein expressions in tumors.
|
28514905 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High expression of p53, Ki67, cyclin A and cyclin B1 was inversely correlated with the papillary morphology of the tumor and positively with tumor grade and T-stage.
|
29970521 |
2018 |