|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In contrast, no BCL10 mutations were found in our series of MALT lymphomas.
|
10665648 |
1999 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Mutant BCL10 overexpression might have a twofold lymphomagenic effect: loss of BCL10 pro-apoptosis may confer a survival advantage to MALT B-cells, and constitutive NF-kappaB activation may provide both anti-apoptotic and proliferative signals mediated via its transcriptional targets.
|
10319863 |
1999 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Bcl10 expressed in a MALT lymphoma exhibited a frameshift mutation resulting in truncation distal to the CARD.
|
9989495 |
1999 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
FusionGene
|
disease |
ORPHANET |
Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).
|
10319863 |
1999 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Mutations within the BCL10 coding region resulting in truncated BCL10 proteins with loss of their proapoptotic function and preservation of their NF-kappaB activating function were detected in MALT lymphoma.
|
10942247 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study.
|
11120333 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Another gene involved in the regulation of apoptosis, the BCL10 gene, has been cloned from a MALT lymphoma cytogenetically characterized by the t(1;14)(p22;q32).
|
10797525 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The Bcl10 gene was identified through characterization of the t(1;14)(p22;q32) associated with mucosa-associated lymphoid tissue (MALT) lymphoma.
|
10886211 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
BCL10 was found to have truncated mutations at a high frequency in MALT (mucosa-associated lymphoid tissue) B cell lymphomas.
|
10790217 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma.
|
11066079 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The human paracaspase prodomain binds Bcl10, a protein involved in the t(1;14)(p22;q32) translocation of mucosa-associated lymphoid tissue (MALT) lymphoma.
|
11090634 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
BCL10 is directly involved in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma.
|
10845924 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Gastrectomy specimens of four MALT lymphoma cases were studied by microdissection and clone-specific polymerase chain reaction (CS-PCR) and of a further case with t(1;14)(p22;q32) by immunohistochemistry for BCL10 protein, which acted as a tumour marker for tumour cells carrying the translocation.
|
11113866 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines.
|
11079291 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The BCL10 gene was identified at the breakpoint region of the t(1;14)(p22;q32) translocation in mucosa-associated lymphoid tissue lymphoma.
|
11372735 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
BCL10, which was identified as a gene altered in mucosa-associated lymphoid tissue lymphoma, has been mapped at 1p22.
|
11376806 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The intracellular pro-apoptotic molecule bcl-10 is frequently mutated in mucosa-associated lymphoid tissue (MALT) lymphomas and various non-hematologic malignancies.
|
11397650 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Nuclear BCL10 expression was seen in 28 of 53 (53%) of MALT lymphomas.
|
11493468 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors.
|
11605060 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
RT-PCR showed higher density bands of Bcl10 in MALT lymphomas than in RLA.
|
11445840 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The occurrence of genomic BCL10 mutations in 35 gastric MALT-type lymphomas with or without t(11;18)(q21;q21) (10 and 25 cases, respectively) was investigated.
|
11830492 |
2002 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
BCL10 is a tumour suppressor gene originally cloned from a t(1;14)(p22;q32) breakpoint in a case of mucosa-associated lymphoid tissue (MALT) lymphoma.
|
11748643 |
2002 |