CCND2, cyclin D2, 894

N. diseases: 241; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 Biomarker disease BEFREE Furthermore, Bmi-1 and Cyclin D2 were found to be positively regulated by USP22, which may have mediated the tumorigenic effects of USP22 in human colon cancer. 31612065 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 GeneticVariation disease GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 GeneticVariation disease GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 Biomarker disease RGD For example, genes involved in inflammation and matrix proteases and a cell cycle regulator gene, cyclin D2, were highly expressed in colon cancers. 15059925 2004
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 Biomarker disease CTD_human For example, genes involved in inflammation and matrix proteases and a cell cycle regulator gene, cyclin D2, were highly expressed in colon cancers. 15059925 2004
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3
0.600 Biomarker disease GENOMICS_ENGLAND De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. 24705253 2014
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3
0.600 GeneticVariation disease UNIPROT De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. 24705253 2014
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3
0.600 Biomarker disease GENOMICS_ENGLAND De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. 24705253 2014
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3
0.600 CausalMutation disease CLINVAR De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. 24705253 2014
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome
0.500 Biomarker disease CTD_human A Novel CCND2 Mutation in a Previously Reported Case of Megalencephaly and Perisylvian Polymicrogyria with Postaxial Polydactyly and Hydrocephalus. 29642246 2018
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome
0.500 GermlineCausalMutation disease ORPHANET De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. 24705253 2014
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome
0.500 Biomarker disease CTD_human De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. 24705253 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 Biomarker disease BEFREE The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance. 31511084 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 Biomarker disease BEFREE Silencing of CCND2 in SW480 and HT29 CRC cell lines leading to reduced cell proliferative and migrative rates, and enhanced apoptotic rate. 31729531 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 Biomarker disease CTD_human Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 AlteredExpression disease BEFREE Our results showed that miR-1297 expression was downregulated in clinical CRC specimens, and such downregulation was associated with upregulated levels of CCND2 expression. 28933597 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease BEFREE We found that rs10795668 in FLJ3802842 and rs4631962 in CCND2 were significantly associated with CRC risk in the Taiwanese population. 24968322 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease GWASDB Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.450 GeneticVariation disease BEFREE We evaluated the implication of USP22 and the candidate targets, such as B-cell-specific murine leukemia virus integration site-1 (BMI-1), cellular homolog of avian myelocytomatosis virus oncogene (c-Myc), cyclin D2, inhibitor of cyclin-dependent kinase (CDK) 4 (p16INK4a), and an alternate reading frame product of the CDKN2A locus (p14ARF), in matched samples comprising carcinoma and adjacent non-cancerous mucosa from 82 patients with CRC using quantitative reverse transcription-polymerase chain reaction and immunostaining analyses. 21039844 2010