|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, restoration of Wnt3a expression partially reversed the tumor suppressor action of miR‑485 in RB cells.
|
30896857 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the effect was not attributable to the interruption of T-cell-intrinsic β-catenin signaling, because Wnt3a/β-catenin activation correlated with enhanced, not reduced, T-cell effector functions both <i>ex vivo</i> and <i>in vitro</i> Adoptively transferred CD8<sup>+</sup> T cells, not directly exposed to the anti-Wnt3a antibody but infiltrating previously Wnt3a-neutralized tumors, also showed improved functions.
|
30018042 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt3a blockade improved the capacity of T naïve cells to differentiate into effector cells <i>in vitro</i> However, Wnt3a blockade did not affect the function and phenotype of differentiated, partially exhausted, tumor-infiltrating T cells <i>ex vivo</i> Taken together, our data suggest that Wnt3a blockade halts the capacity of Wnt/β-catenin signaling to inhibit the differentiation of T naïve cells, but it does not restore the dysfunction of differentiated T cells, in the tumor setting.<i></i>.
|
30018041 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For this purpose, the profiles (expression/methylation/deletion) of β-catenin, p-β-catenin (Y654), Wnt3a, and APC were studied in disease free normal cervical epithelium (n = 9), adjacent normal cervical epithelium of primary tumors (n = 70), CIN (n = 28), CACX (n = 102) samples, and two CACX cell lines (HeLa and SiHa).
|
29079964 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we found that Wnt3a and its target gene c‑Myc showed higher expression in tumour tissues than normal liver tissues in HCC patients; 71.8% of the cases studied had high Wnt3a and c‑Myc expression levels (n=32); Wnt3a expression positively correlated with its target genes MMP‑7 and c‑Myc.
|
28902357 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
WNT3a was overexpressed at the protein and mRNA levels in malignant astrocytic tumors and cell lines.
|
26708597 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The member 3a of Wingless-type MMTV integration site family (Wnt3a) as an oncogene is overexpressed in many kinds of tumors with a worse outcome.
|
26577850 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we demonstrated that GPC5 could suppress the Wnt/β-catenin signaling by binding to Wnt3a at the cell surface, which mediated its function as a tumor suppressor.
|
27157618 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mouse xenograft model showed that Wnt3a-overexpressing cells grew into larger tumor masses and formed more VM than the control cells.
|
26266404 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Wnt3a expression in primary tumors was significantly associated with lymph node involvement (p = 0.038) and MMP-9 expression in the primary tumor (p = 0.0387), mesenchyme adjacent to tumor (p = 0.022) and metastatic site (p = 0.004).
|
24564183 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our study indicates Wnt/β-catenin signaling pathway as an essential driver of glioma tumorigenesis, recognizing role of Wnt3a as an oncogene and thereby offering novel therapeutic strategies for management of these tumors.
|
23337036 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Also, core protein increases cell proliferation rate and promotes Wnt3A-induced tumor growth in the xenograft tumor model of human HCC.
|
22110662 |
2011 |