Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Pharmacological targeting of TRPA1 and ET<sub>A</sub>R-PKA pathway may provide effective strategies to alleviate pain conditions associated with ET-1. 30990108 2020
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE WaTx is a unique pharmacological probe for dissecting TRPA1 function and its contribution to acute and persistent pain. 31447178 2019
CUI: C0030193
Disease: Pain
Pain
0.500 AlteredExpression phenotype BEFREE Data in our study provided evidence that pain upon injection of clinical aqueous etomidate formulations is not an unspecific effect of hyperosmolarity but rather due to a specific action mediated by activated nociceptive TRPA1 and TRPV1 ion channels in sensory neurons. 30345869 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Knockout of TRPA1 also attenuated the β-alanine-induced pain behavior in CCI models. 30148678 2019
CUI: C0030193
Disease: Pain
Pain
0.500 AlteredExpression phenotype BEFREE TRPA1 channels expressed in the central nervous system (CNS) have a critical role in the modulation of cortical spreading depression (CSD), which is a key pathophysiological basis of migraine pain. 31835593 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Molecular docking and site-directed mutagenesis analyses suggested that saikosaponins bind to the hydrophobic pocket in TRPA1 near the Asn855 residue, which, when mutated to Ser, was previously associated with enhanced pain perception in humans. 31782210 2019
CUI: C0030193
Disease: Pain
Pain
0.500 PosttranslationalModification phenotype BEFREE In this study, we hypothesized that TRPA1 promoter methylation regulates pain sensitivity of patients with multisomatoform disorder (MSD). 31455424 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Moreover, TrpA1 and TrpV1 receptors may, respectively, mediate symptoms of chronic itch and pain. 31107888 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE In this issue of Cell, King et al.(2019) have discovered a cell penetrating peptide isolated from the venom of the Australian Black Rock scorpion that activates the TRPA1 receptor in a unique way to induce pain. 31474364 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE In conclusion, the actions of MG through TRPA1 activation on predominantly mechano-insensitive C fibers might be involved in spontaneously perceived pain in diabetic neuropathy and hyperalgesia as well as allodynia. 31219946 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE In the light of current controversies on the role of human TRPA1 ion channels in cold pain perception, the present observations demonstrating a lack of association of TRPA1 channel expression with cold sensitivity-related measures reinforce doubts about involvement of this channel in cold pain in humans. 31343541 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. 31184584 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE TRPA1 responds to diverse exogenous and endogenous stimuli associated with pain and inflammation. 31488616 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE The observation that the TRPA1 irritant cinnamaldehyde induced heat hyperalgesia at an effect sizes comparable with that of capsaicin attributes TRPA1 a role in human heat-induced pain. 30664549 2019
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Thus, T-type Ca<sup>2+</sup> channel may be a potential target for TRPA1-related pain. 29282753 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE These results suggest that endothelin-1 production following oral bacterial invasion via ulcerative regions elicits TRPA1-mediated spontaneous pain. 29518348 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Antioxidants or TRPA1 antagonists in the CeA attenuated both nociceptive and affective pain in SNI animals but not in sham controls or in a control injection site. 29274353 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain. 30245393 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Microinjection of the TRPA1 agonist allyl isothiocyanate (AITC) onto the dura mater produced migraine-like pain for 3h as measured by depression of home cage wheel running. 29111112 2018
CUI: C0030193
Disease: Pain
Pain
0.500 AlteredExpression phenotype BEFREE Using behavioral readouts of pain hypersensitivity induced by angiotensin II (Ang II) injection into mouse hindpaws, our study shows that activation of the type 2 Ang II receptor (AT2R) and the cell-damage-sensing ion channel TRPA1 are required for peripheral mechanical pain sensitization induced by Ang II in male and female mice. 29976627 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE Thus, this study showed the involvement of the TRPA1 receptor in the nociception and inflammation caused by thermal injury and suggested that TRPA1 antagonists might be useful as novel treatments for pain and inflammation by topical application. 30236550 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE We find that intradermal cheek injection of miR-711 induces TRPA1-depedent itch (scratching) without pain (wiping) in naive mice. 30033153 2018
CUI: C0030193
Disease: Pain
Pain
0.500 AlteredExpression phenotype BEFREE We concluded that PB played a critical role in the development of pain-like signs in a GWI rat model and that shifts in Na<sub>v</sub>1.9 and TRPA1 activity were critical to the expression of these pain behaviors. 29803855 2018
CUI: C0030193
Disease: Pain
Pain
0.500 Biomarker phenotype BEFREE In this study, we found that PTHrP induces both heat and mechanical hypersensitivity, that are dependent on the pain-transducing <i>t</i>ransient <i>r</i>eceptor <i>p</i>otential channel family <i>v</i>anilloid, member-1 (TRPV1), but not the mechano-transducing TRPV4 and TRPA1 ion channels. 29497363 2018
CUI: C0030193
Disease: Pain
Pain
0.500 GeneticVariation phenotype BEFREE This indicates a role of the TRPA1 and TRPV1 next-generation sequencing-based genetic pattern in the modulation of the individual response to heat-related pain phenotypes. 29596157 2018