CCNF, cyclin F, 899

N. diseases: 43; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma 		0.010 AlteredExpression disease BEFREE In addition, increased IDH1<sup>R132H</sup> levels correlated with reduced cyclin F levels in increasing grades of glioma. 30254149 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.010 AlteredExpression disease BEFREE Our original in silico analysis, not published elsewhere before, revealed that high expression of cyclin F in melanoma patients is associated with worse overall survival. 29767233 2018
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.010 Biomarker disease BEFREE These data will support further in vitro and in vivo studies on the involvement of cyclin F in skin cutaneous melanoma. 29767233 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE These findings highlight a novel aspect of cyclin F functions in inhibiting tumorigenesis and provide mechanistic insights into regulation of <i>IDH1<sup>R132H</sup></i><b>Significance:</b> These findings reveal mechanistic insights into the key role of the cyclin F-RBPJ axis in response to metabolic stress in cancer cells.<i></i>. 30254149 2018
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.010 Biomarker disease BEFREE Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. 28652210 2017
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.010 AlteredExpression disease BEFREE In a gene expression analysis performed to identify novel gene modulations associated with cell cycle dysregulation during HIV-1 infection in CD4<sup>+</sup> T cells, we observed down-regulation of the cyclin F gene (<i>CCNF</i>). 28184007 2017
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.010 GeneticVariation disease BEFREE Interrogation of international cohorts identified additional novel CCNF variants in familial and sporadic ALS and FTD. 27080313 2016
CUI: C0343640
Disease: African Burkitt's lymphoma
African Burkitt's lymphoma 		0.010 GeneticVariation disease BEFREE Recurrent mutations in two genes not previously associated with eBL were identified in 20% of tumors: RHOA and cyclin F (CCNF). 26468873 2015
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.010 GeneticVariation group BEFREE A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). 7896286 1994
CUI: C3149841
Disease: POLYCYSTIC KIDNEY DISEASE 1
POLYCYSTIC KIDNEY DISEASE 1 		0.010 GeneticVariation disease BEFREE A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). 7896286 1994
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 Biomarker disease BEFREE CCNF), and genes known to interact with breast cancer-associated genes (e.g. 22446932 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 Biomarker disease BEFREE CCNF), and genes known to interact with breast cancer-associated genes (e.g. 22446932 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE In this review the role of multiparameter analyses of cell cycle regulatory proteins in breast cancer will be outlined with special attention to pattern analyses as well as the definition of two contrasting pathways in tumorigenesis defined by either cyclin D1 or cyclin F overexpression. 11883531 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE In this review the role of multiparameter analyses of cell cycle regulatory proteins in breast cancer will be outlined with special attention to pattern analyses as well as the definition of two contrasting pathways in tumorigenesis defined by either cyclin D1 or cyclin F overexpression. 11883531 2002
CUI: C0236642
Disease: Pick Disease of the Brain
Pick Disease of the Brain 		0.030 Biomarker disease BEFREE Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. 28652210 2017
CUI: C0236642
Disease: Pick Disease of the Brain
Pick Disease of the Brain 		0.030 GeneticVariation disease BEFREE Mutations of CCNF gene is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China. 28281833 2017
CUI: C0236642
Disease: Pick Disease of the Brain
Pick Disease of the Brain 		0.030 GeneticVariation disease BEFREE CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. 27080313 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE These findings highlight a novel aspect of cyclin F functions in inhibiting tumorigenesis and provide mechanistic insights into regulation of <i>IDH1<sup>R132H</sup></i><b>Significance:</b> These findings reveal mechanistic insights into the key role of the cyclin F-RBPJ axis in response to metabolic stress in cancer cells.<i>Cancer Res; 78(22); 6386-98.©2018 AACR</i>. 30254149 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE There is little evidence concerning the role of cyclin F in cancer. 29767233 2018
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia 		0.040 GeneticVariation disease BEFREE In this study, we examined the ALS/FTD-causing p.Ser621Gly (p.S621G) mutation in cyclin F and its effect upon downstream Lys48-specific ubiquitylation in transfected Neuro-2A and SH-SY5Y cells. 28852778 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE These findings highlight a novel aspect of cyclin F functions in inhibiting tumorigenesis and provide mechanistic insights into regulation of <i>IDH1<sup>R132H</sup></i><b>Significance:</b> These findings reveal mechanistic insights into the key role of the cyclin F-RBPJ axis in response to metabolic stress in cancer cells.<i>Cancer Res; 78(22); 6386-98.©2018 AACR</i>. 30254149 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE There is little evidence concerning the role of cyclin F in cancer. 29767233 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE In this review, we evaluate the current literature on the function of cyclin F with an emphasis on its roles in cancer and neurodegeneration. 28652210 2017
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia 		0.040 Biomarker disease BEFREE Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. 28652210 2017
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia 		0.040 GeneticVariation disease BEFREE Our result indicates that the mutation of CCNF is rare in patients with ALS and FTD from Mainland China. 28281833 2017