|
Immunologic Deficiency Syndromes
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we employed the fruit fly Drosophila melanogaster to interrogate the role of the immune deficiency (Imd) pathway receptor peptidoglycan recognition protein LE (PGRP-LE) in the regulation of the fly's response to the insect pathogen Photorhabdus luminescens and the insect/human pathogen P. asymbiotica.
|
31404632 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.030 |
Biomarker
|
group |
BEFREE |
Surprisingly, of the classic Imd pathway components, only Relish and the PGRP receptors were involved in salivary gland degradation.
|
30463009 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we provide evidence that the short-chain fatty acid acetate is a microbial metabolic signal that activates signaling through the enteroendocrine IMD pathway in a PGRP-LC-dependent manner.
|
29937377 |
2018 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of Pglyrp1/PGLYPR‑1 in RA is poorly understood.
|
30431075 |
2019 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Involvement of a short-type peptidoglycan recognition protein (PGRP) from Chinese giant salamanders Andrias davidianus in the immune response against bacterial infection.
|
30017855 |
2018 |
|
Bacterial Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
A short period of desiccation-elevated peptidoglycan recognition protein-LC (PGRP-LC) expression in MTs, increased antimicrobial peptide (AMP) gene induction, and protected animals from bacterial infection.
|
29855367 |
2018 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The association study in a discovery sample of 200 French trio families revealed a significant association with RA for one SNP, PGLYRP1-rs2041992 (p = 0.019); this association was stronger in trios where RA patients carried the HLA-DRB1 shared epitope (SE) (p = 0.003).
|
25221852 |
2015 |
|
Chronic Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Initial periodontal therapy is effective in decreasing GCF PGRP-1 levels in both smokers and non-smokers with CP.
|
31587460 |
2020 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Few studies report the role of PGRP in viral infection.
|
31031766 |
2019 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease.
|
28846062 |
2018 |
|
Periodontal Pocket
|
0.010 |
Biomarker
|
disease |
BEFREE |
sTREM-1 and PGLYRP1 are elevated in patients with CKD with poor oral health and positively correlate with number of active periodontal pockets after oral infection therapy.
|
28846062 |
2018 |
|
Oral infection
|
0.010 |
Biomarker
|
group |
BEFREE |
Hence, the salivary sTREM-1/PGLYRP1 axis could be useful as a diagnostic marker for oral infection within patients with CKD.
|
28846062 |
2018 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim of the study is to investigate association of sTREM-1 and PGLYRP1 with oral inflammatory burden among patients with chronic kidney disease (CKD) at predialysis and posttransplantation stages.
|
28846062 |
2018 |
|
Diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Transcriptional analysis of peptidoglycan recognition proteins (PGRPs, including <i>PGLYRP-1</i>, <i>PGLYRP-2</i>, and <i>PGLYRP-3</i>) using real-time PCR revealed that diarrhea induced the upregulation of PGRPs in the cecum and duodenum.
|
29201570 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The cytotoxic Tag7-Hsp70 complex is secreted by lymphocytes after interaction with the HLA-negative tumors.
|
27868339 |
2017 |
|
Gram-Positive Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
These implied that skHbs could involve in the innate immune responses to Gram-positive bacterial infection directly with their amphipathic structures and indirectly by increasing ROS production through PGRP triggering Toll pathway.
|
28238912 |
2017 |
|
ST segment elevation myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data suggested that PGLYRP1, IRAK3 and VNN3 are more specific and sensitive diagnostic biomarkers for STEMI than traditional CK-MB or troponin.Blood transcriptome scans of ACS evidenced early stage molecular markers for STEMI.
|
26025919 |
2015 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Common variants in PGLYRP genes are associated with PD risk in two independent studies.
|
24838182 |
2014 |
|
Ulcerative Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrate that genetic variants in PGLYRP genes associate with CD and UC and may provide a novel insight into the mechanism of pathogenesis of IBD.
|
23840689 |
2013 |
|
Crohn Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified 16 polymorphisms in the four PGLYRP genes that significantly associated with CD, UC, and/or subgroups of patient populations.
|
23840689 |
2013 |
|
Inflammatory Bowel Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease.
|
23840689 |
2013 |
|
Psoriasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A five-SNP haplotype of PGLYRP SNPs associated significantly with psoriasis.
|
18643845 |
2009 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A phase I/II trial was undertaken to define the feasibility, safety and antitumor effects of the autologous vaccine prepared by transferring tag7/PGRP-S gene into malignant melanoma and renal cell carcinoma cells.
|
15598955 |
2005 |
|
Septicaemia due to gram-negative organism, unspecified
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we report a mutation in a gene coding for a putative transmembrane protein, PGRP-LC, which reduces survival to Gram-negative sepsis but has no effect on the response to Gram-positive bacteria or natural fungal infections.
|
11912488 |
2002 |