|
Abnormality of bone mineral density
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of cardiovascular system morphology
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription‑quantitative PCR (RT‑qPCR) and western blot analysis were performed to investigate the expression and post‑translational regulation of SEMA5A in lung adenocarcinoma cell lines.
|
31789397 |
2020 |
|
Alcoholic Intoxication, Chronic
|
0.310 |
Biomarker
|
disease |
BEFREE |
In addition, ALK, CASC4, and SEMA5A were strongly associated with alcohol dependence (p<2 × 10(-5)) in the meta-analysis.
|
21703634 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In addition, ALK, CASC4, and SEMA5A were strongly associated with alcohol dependence (p<2 × 10(-5)) in the meta-analysis.
|
21703634 |
2011 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
When applied to real GWAS data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), our method detected two groups of SNPs: one in a region containing the apolipoprotein E (APOE) gene, and another in a region close to the semaphorin 5A (SEMA5A) gene.
|
28626864 |
2017 |
|
Amino acids measurement
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
23251661 |
2012 |
|
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These effects are plausibly compromised in high-grade human astrocytomas in which Sema5A expression is markedly reduced, hence leading to infiltrative and anaplastic characteristics.
|
21706053 |
2012 |
|
Autism Spectrum Disorders
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We then used Sanger sequencing to search for deleterious variants affecting SEMA5A in 142 patients with ASD.
|
26395558 |
2016 |
|
Autism Spectrum Disorders
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (<i>SEMA5A</i>) for 250 Korean trios including children with ASDs.
|
29209394 |
2017 |
|
Autism Spectrum Disorders
|
0.040 |
Biomarker
|
disease |
BEFREE |
Of these, we focused on Sema5a, a gene involved in axon guidance, spine dynamics, Parkinson's disease and autism spectrum disorders.
|
31509188 |
2019 |
|
Autism Spectrum Disorders
|
0.040 |
Biomarker
|
disease |
BEFREE |
We take a step towards better understanding of the significance of SEMA5A pathways in autism that can guide interpretation of many other genetic results in ASDs.
|
23575222 |
2013 |
|
Autistic Disorder
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Constitutional downregulation of SEMA5A expression in autism.
|
17028446 |
2006 |
|
Autistic Disorder
|
0.340 |
Biomarker
|
disease |
BEFREE |
We also demonstrated that expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene.
|
19812673 |
2009 |
|
Autistic Disorder
|
0.340 |
Biomarker
|
disease |
CTD_human |
Constitutional downregulation of SEMA5A expression in autism.
|
17028446 |
2006 |
|
Autistic Disorder
|
0.340 |
Biomarker
|
disease |
BEFREE |
This study supports newly recognized effects of aberrant SEMA5A and CTNND2 dosage on severity of autistic and cognitive phenotypes.
|
26601658 |
2016 |
|
Autistic Disorder
|
0.340 |
Biomarker
|
disease |
LHGDN |
Constitutional downregulation of SEMA5A expression in autism.
|
17028446 |
2006 |
|
Autistic Disorder
|
0.340 |
Biomarker
|
disease |
BEFREE |
We take a step towards better understanding of the significance of SEMA5A pathways in autism that can guide interpretation of many other genetic results in ASDs.
|
23575222 |
2013 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Semaphorin 5A (Sema 5A) is involved in several autoimmune diseases through the regulation of immune cells.
|
28912336 |
2017 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Semaphorin5A (Sema5A) is involved essentially in immune cell regulation and is also implicated in the pathogenesis of autoimmune disorders.
|
28063160 |
2017 |
|
Byzanthine arch palate
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Ectopic expression of mouse full-length Sema5A in Panc1 (SEMA5A negative) cells significantly (p < 0.05) enhanced tumorigenesis, growth and metastasis in vivo as well as proliferation, invasiveness and homotypic aggregation in vitro.
|
20073063 |
2010 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The present study suggests that overexpression of semaphorin 5A may contribute to gastric carcinogenesis, which reveals a novel expression and function of semaphorin 5A outside the nervous system and adds more weight to our knowledge of semaphorin 5A.
|
20026339 |
2010 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Semaphorin 5A and protein phosphatase 1F are the common genes represented as major hubs in both the smoking and cancer related network.Six pathways, e.g. cell cycle, DNA replication, RNA transport, protein processing in endoplasmic reticulum, vascular smooth muscle contraction and endocytosis were commonly involved in smoking and lung cancer when comparing the top ten selected pathways.
|
22789435 |
2013 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
The importance of NO as a key signaling molecule was highlighted by inhibition of the NP-SEMF beneficial effects in the rat stroke model after blocking NO synthase (NOS).
|
31275094 |
2019 |