|
Breast Carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that RNF2, encoding RING1B, and canonical PRC1 (cPRC1) genes are overexpressed in breast cancer.
|
30139998 |
2018 |
|
Breast Carcinoma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
PRC1 overexpression predicts poor disease-free survival of patients with breast carcinomas.
|
27505863 |
2016 |
|
Breast Carcinoma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
Breast Carcinoma
|
0.470 |
Biomarker
|
disease |
CTD_human |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
Breast Carcinoma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
Breast Carcinoma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
Breast Carcinoma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer.
|
18289367 |
2008 |
|
Breast Carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Our result showed that a vector containing the PRC1 or RRM2 promoter could be used for breast cancer specific overexpression in gene therapy.
|
18587273 |
2008 |
|
Breast Carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
Treatment of breast cancer cells with small interfering RNA against PRC1 effectively suppressed its expression and inhibited the growth of breast cancer cell lines T47D and HBC5.
|
17233835 |
2007 |
|
Breast Carcinoma
|
0.470 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of breast
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that RNF2, encoding RING1B, and canonical PRC1 (cPRC1) genes are overexpressed in breast cancer.
|
30139998 |
2018 |
|
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
CTD_human |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer.
|
18289367 |
2008 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our result showed that a vector containing the PRC1 or RRM2 promoter could be used for breast cancer specific overexpression in gene therapy.
|
18587273 |
2008 |
|
Malignant neoplasm of breast
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Treatment of breast cancer cells with small interfering RNA against PRC1 effectively suppressed its expression and inhibited the growth of breast cancer cell lines T47D and HBC5.
|
17233835 |
2007 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
MiR-194 was downregulated while PRC1 was upregulated in HCC tissues.
|
30948333 |
2019 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
A combined treatment of taxol/shPRC1 results in 90% suppression of tumor growth in subcutaneous HCC xenograft models.
|
29748662 |
2018 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.
|
30145863 |
2018 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In clinical specimens, high expression of PRC1(immunostaining score≥3) in HCC cells predicted an unfavorable postoperative survival of HCC patients(<i>P</i>=0.019), especially for whom received postoperative chemotherapy(<i>P</i>=0.002).
|
28382142 |
2017 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
PRC1 expression was associated with early HCC recurrence and poor patient outcome.
|
26941395 |
2016 |
|
Mammary Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
|
25038754 |
2014 |