PRC1, protein regulator of cytokinesis 1, 9055

N. diseases: 73; N. variants: 8
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 AlteredExpression disease BEFREE Here, we show that RNF2, encoding RING1B, and canonical PRC1 (cPRC1) genes are overexpressed in breast cancer. 30139998 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 AlteredExpression disease BEFREE PRC1 overexpression predicts poor disease-free survival of patients with breast carcinomas. 27505863 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 GeneticVariation disease BEFREE Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04). 27053251 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 Biomarker disease CTD_human In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)). 25038754 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 GeneticVariation disease GWASCAT In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)). 25038754 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 GeneticVariation disease BEFREE In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)). 25038754 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 GeneticVariation disease BEFREE The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer. 18289367 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 Biomarker disease BEFREE Our result showed that a vector containing the PRC1 or RRM2 promoter could be used for breast cancer specific overexpression in gene therapy. 18587273 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 AlteredExpression disease BEFREE Treatment of breast cancer cells with small interfering RNA against PRC1 effectively suppressed its expression and inhibited the growth of breast cancer cell lines T47D and HBC5. 17233835 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.470 GeneticVariation disease CLINVAR