Global developmental delay
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Poor school performance
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ash2 was expressed in 84.4% of hepatocellular carcinomas (38/45) and correlated directly with H3K4diMe modification (correlation coefficient r = 0.53) and LSD1 expression (r = 0.35).
|
19896696 |
2010 |
MIXED LINEAGE LEUKEMIA
|
0.020 |
Biomarker
|
disease |
BEFREE |
ASH2L encodes a trithorax group protein that is a core component of all characterized mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes.
|
28185526 |
2017 |
leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
ASH2L protein levels in primary leukemia patient samples have not yet been defined.
|
28185526 |
2017 |
Childhood Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
ASH2L protein levels in primary leukemia patient samples have not yet been defined.
|
28185526 |
2017 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association study of early menopause and the combined impact of identified variants.
|
23307926 |
2013 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study of early menopause and the combined impact of identified variants.
|
23307926 |
2013 |
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma.
|
31718694 |
2019 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
circ-ASH2L play an important role in tumor invasion, and high circ-ASH2L may be a useful marker of PDAC diagnosis or progression.
|
31718694 |
2019 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
circ-ASH2L play an important role in tumor invasion, and high circ-ASH2L may be a useful marker of PDAC diagnosis or progression.
|
31718694 |
2019 |
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Circ-ASH2L served as a miRNA sponge for miR-34a and promoted tumor progression in vivo.
|
31718694 |
2019 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Depletion of ASH2 ameliorated cancer cell migration and invasion in an MMP9-dependent manner.
|
25746000 |
2015 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Depletion of ASH2 ameliorated cancer cell migration and invasion in an MMP9-dependent manner.
|
25746000 |
2015 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Depletion of ASH2 ameliorated cancer cell migration and invasion in an MMP9-dependent manner.
|
25746000 |
2015 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that ZNF479 regulates MT-1 expression by modulating ASH2L in HCC.
|
31138789 |
2019 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
|
26414677 |
2015 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|
22267201 |
2012 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|
22267201 |
2012 |
Schizophrenia
|
0.200 |
Biomarker
|
disease |
RGD |
Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex.
|
23932495 |
2014 |
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth.
|
31251903 |
2019 |
Liquid Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth.
|
31251903 |
2019 |
leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.
|
30488017 |
2018 |
Childhood Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.
|
30488017 |
2018 |
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, we investigated dimethylation of histone H3 at lysine 4 (H3K4diMe) and H3K4 methylating (Ash2 complex) and demethylating enzymes (LSD1) in carcinomas of the hepatic and gastrointestinal tract.
|
19896696 |
2010 |