|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
NAC as a single agent reduces MCT4 stromal expression, which is a marker of glycolysis in breast cancer with reduced carcinoma cell proliferation.
|
29248134 |
2017 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer.
|
21870331 |
2011 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
These results suggest that MCT4 is a potential therapeutic target in defined breast cancer subtypes and reveal novel avenues for combination treatment.
|
25965974 |
2015 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
High expression of MCT1 and MCT4 in tumour tissues was associated with poor patient outcome; further the correlation between MCT1 expression and poor prognosis in breast cancer was further strengthened when combined with MCT4 overexpression in the adjacent adipose tissue.
|
29775610 |
2018 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma.
|
30051648 |
2018 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer.
|
31828433 |
2020 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We found that breast carcinoma cells that prefer bone as a metastatic site have very high extracellular proton efflux and expression of pumps/ion transporters associated with acid-base balance (MCT4, CA9, and V-ATPase).
|
28903357 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
These data suggest that MCT4 may serve as a novel metabolic target to reverse the Warburg effect and limit disease progression in ccRCC.
|
22362593 |
2012 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Orthotopic tumors were created in mice using human renal cell carcinoma (RCC) lines (A498, 786-O, UOK262) with varying expression of lactate dehydrogenase A (<i>LDHA</i>) which catalyzes the pyruvate-to-lactate conversion, and varying expression of monocarboxylate transporter 4 (<i>MCT4</i>) which mediates lactate export out of the cells.
|
30189677 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
As demonstrated for MCT4, CD147 is proposed to be associated with progression in clear cell renal cell carcinoma (ccRCC).
|
26384346 |
2015 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the correlations of monocarboxylate transporter 1 (MCT1) and MCT4, 2 critical transporters for glycolytic metabolism, with various clinicopathological parameters as well as survival of patients with ccRCC and those treated with vascular endothelial growth factor receptor (VEGFR) inhibitors.
|
29657088 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
MCT4 protein expression was upregulated (P < 0.0001) in ccRCC and showed significant association with cancer-related death.
|
23881922 |
2013 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Expression of lactate/H⁺ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses.
|
25456395 |
2015 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer.
|
21870331 |
2011 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
NAC as a single agent reduces MCT4 stromal expression, which is a marker of glycolysis in breast cancer with reduced carcinoma cell proliferation.
|
29248134 |
2017 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer.
|
31828433 |
2020 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results suggest that MCT4 is a potential therapeutic target in defined breast cancer subtypes and reveal novel avenues for combination treatment.
|
25965974 |
2015 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
High expression of MCT1 and MCT4 in tumour tissues was associated with poor patient outcome; further the correlation between MCT1 expression and poor prognosis in breast cancer was further strengthened when combined with MCT4 overexpression in the adjacent adipose tissue.
|
29775610 |
2018 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Through bioinformatics analysis, the high expression of HIF-1α, MCT1 or MCT4 indicate a poor prognosis in glioblastoma.
|
29928884 |
2018 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We have previously shown that glioblastoma stem cells (GSCs) are enriched in the hypoxic tumor microenvironment, and that monocarboxylate transporter-4 (MCT4) is critical for mediating GSC signaling in hypoxia.
|
28655889 |
2017 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Most importantly, MCT4 silencing also slowed GBM intracranial xenograft growth in vivo.
|
24077291 |
2014 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We aim to explore current therapies focused on MCT1 and MCT4 and propose future studies to better understand their role in GBM to optimize future treatment regimens.
|
30416849 |
2018 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
To further explore and validate the blockade of lactic acid export as an anticancer strategy, we disrupted, via zinc finger nucleases, MCT4 and BASIGIN genes in colon adenocarcinoma (LS174T) and glioblastoma (U87) human cell lines.
|
25403912 |
2015 |