Arteriosclerosis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis.
|
16116050 |
2005 |
Atherosclerosis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis.
|
16116050 |
2005 |
Atherosclerotic lesion
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
A passage number- and atherosclerotic lesion-dependent methylation pattern of MCT3 was demonstrated in the CpG island located in exon 2.
|
16116050 |
2005 |
Carcinoma breast stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.
|
17483329 |
2007 |
West Nile viral infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further demonstrate a requirement for the ubiquitin ligase CBLL1 in WNV internalization, a post-entry role for the endoplasmic-reticulum-associated degradation pathway in viral infection, and the monocarboxylic acid transporter MCT4 as a viral replication resistance factor.
|
18690214 |
2008 |
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, both MCT4 and CD147 were more frequently expressed in Lauren's intestinal-type tumours and MCT1/CD147 co-expression was associated with advanced gastric carcinoma, Lauren's intestinal type, TNM staging and lymph-node metastasis.
|
19628385 |
2009 |
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Five genes (AdoRA(2B)at 17p12, CCL2 at 17q12, ACLY at 17q21.2, WIPI1 at 17q24.2, and SLC16A3 at 17q25.3) were significantly (P < 5.13E-11) differentially expressed at least threefold in all serous TOV samples, and all five genes were underexpressed in these TOV samples as compared to the NOSE samples.
|
18028382 |
2009 |
Breast Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer.
|
21870331 |
2011 |
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
BEFREE |
The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer.
|
21870331 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, MCT-3, MG and AZA alone and in combination increased expression of the novel tumour suppressor gene Nur77, important in leukemogenesis, with MG a more potent inducer as a single agent.
|
21253674 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
First, we showed that blocking MCT1/2 in Ras-transformed fibroblasts with AR-C155858 suppressed lactate export, glycolysis, and tumor growth, whereas ectopic expression of MCT4 in these cells conferred resistance to MCT1/2 inhibition and reestablished tumorigenicty.
|
21930917 |
2011 |
Breast Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Here, we used MCT4 immuno-staining of human breast cancer tissue microarrays (TMAs; > 180 triple-negative patients) to directly assess the prognostic value of the "Reverse Warburg Effect."
|
22313602 |
2012 |
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
CTD_human |
Here, we used MCT4 immuno-staining of human breast cancer tissue microarrays (TMAs; > 180 triple-negative patients) to directly assess the prognostic value of the "Reverse Warburg Effect."
|
22313602 |
2012 |
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
"Using the ""reverse Warburg effect"" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers."
|
22313602 |
2012 |
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
"Using the ""reverse Warburg effect"" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers."
|
22313602 |
2012 |
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
"Using the ""reverse Warburg effect"" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers."
|
22313602 |
2012 |
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Consistent with the potential selection of subclones enriched for MCT4 expression during disease progression, MCT4 expression was greater at sites of metastatic disease.
|
22362593 |
2012 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
These data suggest that MCT4 may serve as a novel metabolic target to reverse the Warburg effect and limit disease progression in ccRCC.
|
22362593 |
2012 |
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Androgen-responsive and nonresponsive PCa cells present distinct glycolytic metabolism profiles, which suggest that targeting LDH and MCT4 metabolic pathways may be an important step for the development of new diagnostic and therapeutic strategies in the different stages of PCa.
|
22964025 |
2012 |
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Androgen-responsive and nonresponsive PCa cells present distinct glycolytic metabolism profiles, which suggest that targeting LDH and MCT4 metabolic pathways may be an important step for the development of new diagnostic and therapeutic strategies in the different stages of PCa.
|
22964025 |
2012 |
Renal carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
|
22362593 |
2012 |
Renal Cell Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
|
22362593 |
2012 |
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study has identified several genes of interest, such as HLA-C, SLC16A3, SLC9A8, SLC12A1 and SLC7A2, that require verification of their roles as susceptibility genes for diabetic nephropathy in ethnic Malays with type 2 DM.
|
21360476 |
2012 |
Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, to clarify the role of protein kinase C (PKC) in the regulation of monocarboxylate transporter 4 (MCT4) expression, we examined the regulation mechanism of MCT4 expression in human rhabdomyosarcoma (RD) cells, an in vitro skeletal muscle model.
|
22426323 |
2012 |
Childhood Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, to clarify the role of protein kinase C (PKC) in the regulation of monocarboxylate transporter 4 (MCT4) expression, we examined the regulation mechanism of MCT4 expression in human rhabdomyosarcoma (RD) cells, an in vitro skeletal muscle model.
|
22426323 |
2012 |