Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, adenocarcinoma showed significantly higher incidence of concomitant expression of Ha-ras p21 and fes P85 as compared with other histologic types of lung cancer.
|
1310887 |
1992 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, adenocarcinoma showed significantly higher incidence of concomitant expression of Ha-ras p21 and fes P85 as compared with other histologic types of lung cancer.
|
1310887 |
1992 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, adenocarcinoma showed significantly higher incidence of concomitant expression of Ha-ras p21 and fes P85 as compared with other histologic types of lung cancer.
|
1310887 |
1992 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, adenocarcinoma showed significantly higher incidence of concomitant expression of Ha-ras p21 and fes P85 as compared with other histologic types of lung cancer.
|
1310887 |
1992 |
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Using this panel, we characterized two mutants of p85 (70 and 50 kDa) expressed in the human colon carcinoma cell line, HCC2998.
|
7541019 |
1995 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin.
|
9538131 |
1998 |
Malignant Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin.
|
9538131 |
1998 |
Mood Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
For this reason, messenger RNA expression of three G protein alpha-subunits and of phosphatidylinositol-3 kinase (PI-3 K) regulatory subunit p85 was examined in granulocytes from patients with bipolar or unipolar affective disorder and compared to healthy controls.
|
9857977 |
1998 |
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
We conclude that variations of the REN (or of a nearby) gene that may be in linkage disequilibrium with REN (BglI(-)/MboI(+)) and (BglI(+)/MboI(+)) alleles could play a role in contributing to increased individual's genetic susceptibility to EHT and to stroke.
|
11224002 |
2001 |
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was no significant difference in the abundance of IR, IRS-1, or the p85 regulatory subunit of PI 3K in PCOS (n = 14) compared with control (n = 12) muscle.
|
11440917 |
2001 |
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we describe the cloning of a C-terminal truncated form of p85 expressed in a human lymphoma cell line (CO) with a T cell phenotype derived from a patient with Hodgkin's disease.
|
11986952 |
2002 |
Lymphoproliferative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Recently an oncogenic form of p85 named p65-PI3K lacking the C-terminal SH2 domain has been cloned from an irradiation-induced murine thymic lymphoma and transgenic mice expressing p65-PI3K in T lymphocytes develop a lymphoproliferative disorder.
|
11986952 |
2002 |
Leukemogenesis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first detection of a mutated form of the p85 subunit of PI3-kinase in human hematopoietic cells further underlining a potential role of PI3-kinase/Akt signaling in human leukemogenesis.
|
11986952 |
2002 |
Thymic Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently an oncogenic form of p85 named p65-PI3K lacking the C-terminal SH2 domain has been cloned from an irradiation-induced murine thymic lymphoma and transgenic mice expressing p65-PI3K in T lymphocytes develop a lymphoproliferative disorder.
|
11986952 |
2002 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present work, we have found that Sam68 is tyrosine phosphorylated in peripheral blood mononuclear cells (PBMC) from HIV infected subjects, leading to the formation of signalling complexes with p85 the regulatory subunit of PI3K, GAP and STAT-3, and decreasing its RNA binding capacity.
|
16045742 |
2005 |
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.
|
16131837 |
2005 |
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.
|
16131837 |
2005 |
Carcinogenesis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
These findings lend new insight to how changes in p85 gene dosage or mutations in p85 could lead to the hyper-activation of PI3K and thus contribute towards tumorigenesis.
|
16131837 |
2005 |
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrate that a formulation containing the block copolymer Pluronic P85 and antineoplastic drug doxorubicin (Dox) prevents the development of multidrug resistance in the human breast carcinoma cell line, MCF7.
|
16579640 |
2006 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Mutating sst2-Y71 disabled sst2 to interact with p85 and somatostatin to inhibit PI3K, consequently abrogating sst2's ability to suppress cell survival and tumor growth.
|
16917505 |
2006 |
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Binding of CD95 Ligand to CD95 on glioblastoma cells recruits the Src family member Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
|
18328427 |
2008 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Binding of CD95 Ligand to CD95 on glioblastoma cells recruits the Src family member Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
|
18328427 |
2008 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Binding of CD95 Ligand to CD95 on glioblastoma cells recruits the Src family member Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
|
18328427 |
2008 |
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Binding of CD95 Ligand to CD95 on glioblastoma cells recruits the Src family member Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
|
18328427 |
2008 |
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Notably, p85 and p110 are competed out for their binding to HCV 5' UTR when excess amounts of iron-responsive element (IRE) competitor RNAs are treated.
|
18566883 |
2008 |