Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth. 29588411 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE In vivo, P85 (200 mg/kg/day) and (-)-gossypol (15 mg/kg/day) could be safely injected intravenously over 5 days and enhanced radiation-related tumor control in an A549 xenograft model. 27827005 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE The short isoform p42 Ebp1, which is actual binding partner of ErbB3 has been implicated as a tumor suppressor with many binding partners such as Rb, HDAC2, Sin3A and the p85 subunit of PI3K with HSP70/CHIP, inhibiting its own antiproliferative activity or inhibiting PI3K activity. 27130196 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 AlteredExpression group BEFREE At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. 22878926 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Tumor cell proliferation was comparable, but Mtgr1(-/-) tumors had significantly higher apoptosis rates. 21303973 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Mutating sst2-Y71 disabled sst2 to interact with p85 and somatostatin to inhibit PI3K, consequently abrogating sst2's ability to suppress cell survival and tumor growth. 16917505 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. 9538131 1998