MYOM2, myomesin 2, 9172

N. diseases: 103; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0238124
Disease: Necrotizing fasciitis
Necrotizing fasciitis
0.030 Biomarker disease BEFREE M protein is the most abundant GAS surface protein, and M1 serotype GAS strains are associated with invasive infections, including necrotizing fasciitis and toxic shock syndrome. 28784982 2017
CUI: C0238124
Disease: Necrotizing fasciitis
Necrotizing fasciitis
0.030 GeneticVariation disease BEFREE We present two cases of invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis, one that showed rapidly developing necrotizing fasciitis in a previously healthy man and one that showed severe cellulitis and septic shock even though the bacterium possessed a mutated emm gene, predicted to encode a truncated M protein. 20147644 2010
CUI: C0238124
Disease: Necrotizing fasciitis
Necrotizing fasciitis
0.030 Biomarker disease BEFREE We conclude that the group A streptococcal hyaluronic acid capsule and M protein, but not the cysteine protease, are critical for the development of tissue necrosis, secondary bacteremia, and lethal infection in a murine model of human necrotizing fasciitis. 9691092 1998