Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis.
|
23439055 |
2013 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002).
|
19852851 |
2009 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma.
|
29247993 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans.
|
28266165 |
2017 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma.
|
23380221 |
2013 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients.
|
30950351 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma.
|
28273074 |
2017 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |