Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts.
|
21281963 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis.
|
23439055 |
2013 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002).
|
19852851 |
2009 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics.
|
29694974 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma.
|
29247993 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans.
|
28266165 |
2017 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies.
|
25313073 |
2014 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma.
|
23380221 |
2013 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma.
|
19910030 |
2010 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients.
|
30950351 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
|
23541324 |
2013 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma.
|
31435003 |
2020 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several genes in the TLR-related pathway were associated with atopy and/or asthma [e.g.IL1RL1, BPI, NOD1, NOD2 and MAP3K7IP1].
|
19968634 |
2010 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma.
|
22574108 |
2012 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lung ST2L and toll-like receptor 9 protein expression levels concomitantly increased in a time-dependent manner during fungal asthma.
|
21640974 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma.
|
28273074 |
2017 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study aimed to characterize DNA methylation (DNA-me) in promoter region of IL33, IL1RL1 and CCL26 in asthma and their impacts on transcriptional activity in bronchial epithelial cells (BECs).
|
30468398 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We uncovered several promising tissue-specific regulatory TFs or genes for Alzheimer's disease (e.g.ZIC1 and STX1B) and asthma (e.g.CSF3 and IL1RL1).
|
29378629 |
2018 |