Asthma
|
0.500 |
Biomarker
|
disease |
LHGDN |
Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy.
|
18774397 |
2008 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002).
|
19852851 |
2009 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma.
|
19910030 |
2010 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several genes in the TLR-related pathway were associated with atopy and/or asthma [e.g.IL1RL1, BPI, NOD1, NOD2 and MAP3K7IP1].
|
19968634 |
2010 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts.
|
21281963 |
2011 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lung ST2L and toll-like receptor 9 protein expression levels concomitantly increased in a time-dependent manner during fungal asthma.
|
21640974 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases.
|
21682736 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets.
|
22455494 |
2012 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma.
|
22574108 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma.
|
23380221 |
2013 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis.
|
23439055 |
2013 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
|
23541324 |
2013 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |