Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated <i>IL1RL1</i> SNPs strongly regulate <i>IL1RL1</i> methylation and serum IL1RL1-a levels, yet neither these <i>IL1RL1-</i>methylation CpG sites nor IL1RL1-a levels are associated with asthma.
|
29519908 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
LHGDN |
Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy.
|
18774397 |
2008 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases.
|
21682736 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma.
|
22574108 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma.
|
28273074 |
2017 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets.
|
22455494 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |