IL1RL1, interleukin 1 receptor like 1, 9173

N. diseases: 117; N. variants: 51
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6). 24568840 2014
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis. 23439055 2013
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma. 23380221 2013
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function. 23541324 2013
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease GWASDB Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. 23028483 2012
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma. 22574108 2012
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease GWASCAT Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. 23028483 2012
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets. 22455494 2012
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
CUI: C0004096
Disease: Asthma
Asthma
0.500 AlteredExpression disease BEFREE We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts. 21281963 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease CTD_human Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease GWASDB Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease GWASCAT Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 AlteredExpression disease BEFREE Lung ST2L and toll-like receptor 9 protein expression levels concomitantly increased in a time-dependent manner during fungal asthma. 21640974 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease CTD_human However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases. 21682736 2011
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma. 19910030 2010
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease BEFREE Several genes in the TLR-related pathway were associated with atopy and/or asthma [e.g.IL1RL1, BPI, NOD1, NOD2 and MAP3K7IP1]. 19968634 2010
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). 19198610 2009
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation disease BEFREE Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002). 19852851 2009
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease CTD_human A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). 19198610 2009
CUI: C0004096
Disease: Asthma
Asthma
0.500 Biomarker disease LHGDN Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. 18774397 2008