Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma.
|
31435003 |
2020 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients.
|
30950351 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.
|
30578877 |
2019 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics.
|
29694974 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma.
|
29247993 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study aimed to characterize DNA methylation (DNA-me) in promoter region of IL33, IL1RL1 and CCL26 in asthma and their impacts on transcriptional activity in bronchial epithelial cells (BECs).
|
30468398 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We uncovered several promising tissue-specific regulatory TFs or genes for Alzheimer's disease (e.g.ZIC1 and STX1B) and asthma (e.g.CSF3 and IL1RL1).
|
29378629 |
2018 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated <i>IL1RL1</i> SNPs strongly regulate <i>IL1RL1</i> methylation and serum IL1RL1-a levels, yet neither these <i>IL1RL1-</i>methylation CpG sites nor IL1RL1-a levels are associated with asthma.
|
29519908 |
2018 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans.
|
28266165 |
2017 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
IL-33 Drives Augmented Responses to Ozone in Obese Mice.
|
27472835 |
2017 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma.
|
28273074 |
2017 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies.
|
25313073 |
2014 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |