|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results suggest that reconstitution of deficient TCR zeta chain can reverse the TCR/CD3-mediated signaling abnormalities as well as the defective IL-2 production in T cells of patients with SLE.
|
12847689 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, a higher CD3Z methylation level was significantly correlated with a higher SLE disease activity index and more severe clinical manifestations, such as proteinuria, haemolytic anaemia and thrombocytopenia, whereas VHL hypermethylation was not.
|
27940592 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Thus our study identifies a novel mechanism whereby SRSF1 regulates CD3ζ expression in human T cells and may contribute to the T cell defect in SLE.
|
26134847 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling.
|
11967985 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The absence of these sequences represents a molecular mechanism that contributes to altered TCR zeta-chain expression in lupus.
|
17114503 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that protein expression of the TCR zeta chain was significantly decreased in peripheral T cells from patients with SLE compared to normal controls and patients with systemic sclerosis (SSc).
|
9701029 |
1998 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Serine/arginine-rich splicing factor 1 (SRSF1) binds pre-messenger RNA (pre-mRNA) to regulate AS forms of several genes, including CD3ζ in SLE T cells.
|
29905030 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.
|
25569266 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus.
|
12727645 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Aberrant CD247 transcript variants displaying either spliced exon 7 or short 3'-untranslated region have been detected in SLE T cells, and a recent genome-wide association study reported the existence of new CD247 single-nucleotide polymorphisms in SLE patients.
|
23525753 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We also identified various alternatively spliced forms of the TCR zeta chain resulting from the deletion of individual exons II, VI, or VII, or a combined deletion of exons V and VI; VI and VII; II, III, and IV; or V, VI, and VII in SLE T cells.
|
11407693 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We have demonstrated that the expression of TCR zeta chain is significantly decreased in peripheral blood T cells from SLE patients.
|
15204089 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We previously showed that SLE T cells express decreased levels of the T-cell receptor-CD3ζ chain and forced expression of CD3ζ into SLE T cells restores IL-2 production.
|
23319613 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A significant association between variants in CD247 and SLE was demonstrated in Asian populations.
|
22004975 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
The phosphorylated 21- and 23-kd forms and the detergent-insoluble membrane-associated form of the TCR zeta chain and alternatively spliced zeta chain were significantly decreased in SLE T cells.
|
11817588 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In this review, current knowledge concerning the expression of CD3 zeta chain as well as the mechanisms responsible for abnormal expression of this molecule in systemic lupus erythematosus, rheumatoid arthritis, and childhood idiopathic nephrotic syndrome are summarized.
|
18060371 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Because both the transcription and the translation processes of Elf-1 gene are normal in SLE T cells, our data demonstrate that abnormal posttranslational mechanisms of the Elf-1 protein result in defective expression of functional Elf-1, and consequently, the transcriptional defect of TCR zeta-chain in patients of SLE.
|
12421992 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, the authors review the unique features of CD3 ζ defects observed in SLE and discuss the molecular basis of the defects by recent findings in animal models, single-nucleotide polymorphisms and genome-wide association studies.
|
22460144 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We found reduced CD3ζ expression in NK cells from SLE patients independent of disease activity.
|
29602774 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Recently, it is known that reconstitution of deficient TCR zeta chain in T lymphocytes from SLE patients leads to restoration of impaired IL-2 production upon CD3/CD28 stimulation.
|
16431347 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
We conclude that caspase-3 inhibitors can normalize SLE T cell function by limiting the excessive digestion of CD3zeta-chain and suggest that such molecules can be considered in the treatment of this disease.
|
16116236 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Although attenuated expression of the TCR zeta chain is also observed in patients with cancers, infections and other autoimmune diseases, sustained attenuation of TCR zeta expression and aberrant transcripts are only observed in SLE.
|
16227148 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Latest developments suggest that interplay of abnormal transcriptional factor expression, aberrant mRNA processing/editing, unbiquitination, proteolysis, and the effects of oxidative stress as well as changes in chromatin structure invariably contribute to TCR zeta chain deficiency in SLE T cells.
|
15204087 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated whether Fcepsilon receptor type I gamma chain (FcepsilonRIgamma) could substitute for TCR zeta chain and contribute to T cell signaling in SLE.
|
11352243 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This observation confers that genetic factors causing a decreased level of CD3-zeta in T cells may predispose to SLE incidence.
|
19422667 |
2009 |