AURKB, aurora kinase B, 9212

N. diseases: 161; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.060 AlteredExpression disease BEFREE AURKB was among the most significantly up-regulated kinase-coding genes in TMZ resistant GBM cells according to database GSE68029, moreover, an increased expression of AURKB was closely associated with poor prognosis in glioma and GBM patients. 31563286 2019
CUI: C0017638
Disease: Glioma
Glioma
0.060 Biomarker disease BEFREE Both AURKB and UBE2C were significantly up-regulated in gliomas compared to normal brain tissues and the combined elevation of AURKB and UBE2C were strongly associated with histological classification in glioma. 31353228 2019
CUI: C0017638
Disease: Glioma
Glioma
0.060 Biomarker disease BEFREE Aurora B inhibition with AZD1152-HQPA blocked cell division in four different p53-mutant glioma cell lines (U251, T98G, U373, and U118). 22382783 2012
CUI: C0017638
Disease: Glioma
Glioma
0.060 AlteredExpression disease BEFREE We found that KIF2C and AURKB genes were higher expression in glioma samples when were compared with normal brain tissues. 22130050 2012
CUI: C0017638
Disease: Glioma
Glioma
0.060 Biomarker disease BEFREE To identify candidate apoptosis-sensitizing genes that could be exploited in combination with Aurora kinase inhibitors in malignant glioma, we have carried out global gene expression analysis in a D54MG glioma cell derivative treated with three Aurora kinase inhibitors chosen for their distinctive selectivities: MLN8054 (Aurora A-selective), AZD1152 (Aurora B-selective), and VX-680 (Aurora A/B). 19079141 2009
CUI: C0017638
Disease: Glioma
Glioma
0.060 AlteredExpression disease LHGDN Aurora-B/AIM-1 was highly expressed in high-grade gliomas and its expression was well correlated with histological malignancy and clinical outcomes. 15072448 2004