AURKB, aurora kinase B, 9212

N. diseases: 161; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 AlteredExpression disease BEFREE Osteosarcoma cells (U2-OS and 143B) were treated with specific Lentivirus-Vectors (up or downregulation Aurora-B). 31122179 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 AlteredExpression disease BEFREE Moreover, knocking down the expression of Aurora B effectively reduced the sensitivity of osteosarcoma to HOI-07. 30790360 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 Biomarker disease BEFREE Quantitative real-time PCR (qRT-PCR) was performed to evaluate the expression level of let-7a and Aurora-B (AURKB) in OS tissues and cells. 30568492 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 AlteredExpression disease BEFREE AURKB and PPP2R2B were the significantly up-regulated and down-regulated hub proteins, respectively, in the PPI protein-protein network (PPI) network of primary OS. 27888627 2016
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 Biomarker disease BEFREE The expression of Aurora-B in human OS cell lines U2-OS and HOS cells was inhibited by specific short hairpin RNA (shRNA) lentivirus (AURKB-shRNA lentivirus, Lv-shAURKB) which targeted Aurora-B. 25874486 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 Biomarker disease BEFREE Our previous study indicated that Aurora-B is involved in osteosarcoma (OS) cell invasion and metastasis; however, the mechanism underlying Aurora-B overexpression in OS remains unknown. 25997616 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.070 Biomarker disease BEFREE Targeting of let-7g and Aurora-B may be a novel therapeutic strategy for treating OS. 25197332 2014