VAPA, VAMP associated protein A, 9218

N. diseases: 11; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.030 AlteredExpression disease BEFREE As the formation of VAP-A/NS5A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5A complex and thus inhibited HCV replication. 31384537 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.030 Biomarker disease BEFREE Here, we show that VAPA and VAPB are redundant for HCV infection and that dimerization is not required for their function. 31484747 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.030 Biomarker disease BEFREE In summary, these findings suggest a novel mechanism by which viperin inhibits HCV replication, possibly through binding to host protein hVAP-33 and interfering with its interaction with NS5A. 21957124 2012