|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic testing showed the t(12,22) translocation corresponding to the presence of the EWS/ATF1 hybrid consistent with CCS.
|
27719746 |
2017 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is supported by 11 cases of primary GI CCS with the t(12;22) translocation.
|
18408594 |
2008 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clear cell sarcoma of soft tissue (CCS-ST) is a rare malignant neoplasm characterized by a tumor-defining translocation [t(12;22) (q13;q12)], resulting in the EWS-ATF1 gene fusion.
|
16517477 |
2006 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular methods are sometimes necessary to identify the unique t(12; 22)(q13;q12) translocation and differentiate clear cell sarcoma from melanoma.
|
16519562 |
2006 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reverse transcription-polymerase chain reaction analysis performed on paraffin-embedded tissue showed EWS-ATF1 fusion transcripts representative of the t(12;22) (q13;q12) clear cell sarcoma reciprocal translocation.
|
16021514 |
2005 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
|
15150091 |
2004 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed cytogenetic analyses on a primary and subsequent metastatic CCS that contained the t(12;22), along with other complex karyotypic changes.
|
15104285 |
2004 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings may indicate the possible involvement of the ATF1 gene in clear cell melanoma tumorigenesis, similar to clear cell sarcoma with classical t(12;22) translocation.
|
16285301 |
2003 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The translocation t(12;22)(q13;q12-13) has been reported as specific for clear cell sarcomas.
|
9422325 |
1998 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator.
|
8552387 |
1996 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, six of the translocations, namely the t(11;22), t(21;22), and t(7;22) of Ewing's sarcoma, the t(12;22) of clear cell sarcoma, the t(12;16) of myxoid liposarcoma, and the t(11;22) of desmoplastic small round cell tumor, achieve this following a peculiar pattern, consisting in the fusion of a gene with an RNA-binding domain (EWS or TLS) with a transcription factor gene (FLI1, ERG, ETV1, ATF-1, CHOP, or WT1).
|
7493135 |
1995 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The breakpoints on 22q were in all 5 cases cytogenetically indistinguishable from those seen in Ewing's sarcoma with t(11;22), clear-cell sarcoma with t(12;22), and desmoplastic small round cell tumors with t(11;22).
|
7635565 |
1995 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
They include rearrangement of 8q12 in lipoblastomas, ring chromosomes in atypical lipomas, ring and giant marker chromosomes in well differentiated liposarcomas, t(12;16)(q13;p11) in myxoid liposarcomas, rearrangement of 7p21-22 in low-grade endometrial stromal sarcomas, t(2;13)(q37;q14) in alveolar rhabdomyosarcomas, t(X;18)(p11.2;q11.2) in synovial sarcomas, t(12;22) (q13;q13) in clear cell sarcomas, t(11;22)(q24;q12) in Ewing's sarcomas and peripheral neuroepitheliomas, and t(9;22)(q21-31;q11-12) in extraskeletal myxoid chondrosarcomas.
|
7828142 |
1994 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.
|
8401579 |
1993 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that the finding of the specific translocation t(12;22) may prove to be an important marker in the differential diagnosis of clear cell sarcoma from some other soft tissue sarcomas and malignant melanoma.
|
7685631 |
1993 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
Biomarker
|
disease |
BEFREE |
A similar or identical t(12;22) was recently reported in two of four clear-cell sarcomas.
|
1373311 |
1992 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An identical or similar translocation has previously been reported in this type of tumor, suggesting that the t(12;22) is a primary cytogenetic change in the pathogenesis of a subset of clear-cell sarcomas.
|
1486558 |
1992 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clear cell sarcoma with t(12;22) (q13-14;q12).
|
1797088 |
1991 |