Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study suggests that SNPs (T>C substitution) affect the function of the DLG5 protein and thus play a role in the development of IBD, in particular Crohn's disease.
|
30648106 |
2018 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The study suggests that SNPs (T>C substitution) affect the function of the DLG5 protein and thus play a role in the development of IBD, in particular Crohn's disease.
|
30648106 |
2018 |
Alanine aminotransferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
Serum gamma-glutamyl transferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
Serum Alanine Aminotransferase Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The association of DLG5 polymorphisms with inflammatory bowel disease: a meta-analysis of 25 studies.
|
27338058 |
2016 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, our results strongly suggest that the both polymorphisms of DLG5 are correlated with IBD susceptibility in an ethnic-specific manner.
|
27633114 |
2016 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
|
24910533 |
2014 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
|
24910533 |
2014 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant associations of both DLG5 polymorphisms with the development of CD in the Malaysian patients were observed in this study.
|
22118696 |
2011 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our study does not support the effect of the R30Q DLG5 variant in CeD or IBD predisposition in the Spanish population.
|
20796250 |
2011 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we examined the genetic association of another DLG5 SNP rs2289310" genes_norm="9231">P1371Q (rs2289310) with IBD and its interaction with R30Q in disease susceptibility.
|
22065243 |
2011 |
Serum gamma-glutamyl transferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
22001757 |
2011 |
Serum gamma-glutamyl transferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
22001757 |
2011 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility.
|
19455129 |
2009 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.
|
19455129 |
2009 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We studied the incidence of DLG5 alleles in a population of IBD patients from Pennsylvania.
|
20037206 |
2009 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
As there is substantial crosstalk between CARD-mediated pathways, both CD susceptibility genes, NOD2 and DLG5, may interact functionally to contribute to CD risk.
|
18335190 |
2008 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Discs large homolog 5 (DLG5), a member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, has been associated with Crohn's disease (CD), but its role in the pathogenesis of this inflammatory bowel disease is disputed.
|
18335190 |
2008 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specifically, the significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children.
|
17156146 |
2007 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variants in CARD15, TLR4, NOD1, CARD8, and DLG5 associated with CD were tested as well.
|
17206668 |
2007 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC).
|
16944184 |
2007 |