Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We then knocked a mutation into BRAF encoding the V600E substitution and overexpressed the GREM1 transgene; the organoids were transplanted into colons of NOG mice and growth of xenograft tumors was measured.
|
31622618 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, in immunodeficient B6/ Rag1 <sup>-/-</sup> and NOG mice, the same treatment failed to control tumor growth, further proving that the attenuation of tumor growth by tumor acidity modulation was attributable to the activation of tumor-infiltrating immune cells.
|
30943039 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, introduction of the BMP signaling inhibitor Noggin failed to accelerate tumor formation, suggesting that the tumor-promoting effect of c-Ski depends on the inhibition of TGF-β signaling rather than of BMP signaling.
|
30972853 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transplantation of human iPSC-derived cardiomyocytes (CMs) without treatment into NOG mice consistently induced teratoma/tumour formation, with a substantial number of Ki-67-positive cells in the graft at 4 months post-transplant, whereas iPSC-derived CMs treated with brentuximab vedotin prior to the transplantation did not show teratoma/tumour formation, which was associated with absence of Ki-67-positive cells in the graft over the same period.
|
29487310 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical examination of prostate cancer xenografts showed strong Noggin protein staining on endosteal bone surfaces and in bone lining cells in close proximity to tumor foci.
|
28981962 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The combination of cabozantinib and gefitinib effectively inhibited the growth of HCC78R tumors in an in vivo xenograft model of NOG mice.
|
30053332 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice.
|
28055955 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA TCB activity was characterized on 110 cell lines in vitro and in xenograft tumor models in vivo using NOG mice engrafted with human peripheral blood mononuclear cells.
|
26861458 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, Oct4-overexpressing PC9 cells (PC9-Oct4) significantly formed tumors at 1 × 10 cells/injection in NOG mice as compared to control cells.
|
26996130 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previously published data demonstrated that extinction of QSOX1 promotes tumor growth in NOG mice.
|
24475161 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, results for cE1/noggin, and cE1 mixed with CAF/noggin, suggested that suppression of BMP activity in the cancer cells may have a stronger growth-enhancing effect on the tumor than its suppression in the fibroblastic compartment of the tumor microenvironment.
|
24042462 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NOG expression is acquired during the late events of metastasis, once cells have departed from the primary site, because it is not enriched in primary tumors with high risk of bone relapse.
|
22547073 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that tumor cell Shh expression can induce significant changes in expression of BMP ligands and inhibitors in the stromal microenvironment but that acceleration of LNCaP xenograft tumor growth by Shh over-expression cannot be attributed solely to increased Noggin expression in the tumor stroma.
|
19773112 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, tumor suppressor activity of the BMPs in skin epithelium depends on the local concentrations of noggin and is mediated at least in part via stage-dependent antagonizing of Wnt and Shh signaling pathways.
|
19700758 |
2009 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes.
|
17696196 |
2007 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Noggin overexpression inhibited the formation of the osteoblastic aspect of the lesion in bone and the tumor growth in vivo.
|
16995812 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, inhibition of BMP-2 activity with either recombinant noggin or anti-BMP-2 antibody resulted in a significant reduction in tumor growth.
|
12819188 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NOG-8 infectants formed colonies in soft agar and tumors in nude mice.
|
2812779 |
1989 |