GPR50, G protein-coupled receptor 50, 9248

N. diseases: 31; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 GeneticVariation group BEFREE Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern. 21565467 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 Biomarker group PSYGENET Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern. 21565467 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE To our knowledge this is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. 20371266 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET To our knowledge this is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. 20371266 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 Biomarker group BEFREE Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. 20371266 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 Biomarker group PSYGENET Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. 20371266 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 Biomarker group PSYGENET Disruption of the circadian timing systems: molecular mechanisms in mood disorders. 19708722 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET The positional candidate approach showed an association between bipolar disorder and TRPM2 (21q22.3), GPR50 (Xq28), Citron (12q24), CHMP1.5 (18p11.2), GCHI (14q22-24), MLC1 (22q13), GABRA5 (15q11-q13), BCR (22q11), CUX2, FLJ32356 (12q23-q24), and NAPG (18p11). 17239033 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease BEFREE Our choice of this gene for study was based on a previous report of an association of GPR50 with bipolar disorder and major depressive disorder. 18075476 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET Our choice of this gene for study was based on a previous report of an association of GPR50 with bipolar disorder and major depressive disorder. 18075476 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 Biomarker group BEFREE GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families. 18075476 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 Biomarker group PSYGENET GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families. 18075476 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE Recently an insertion/deletion polymorphism in GPR50, Delta502-505, was found to be associated with BP in a Scottish association sample (P=0.007). 17106423 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET Recently an insertion/deletion polymorphism in GPR50, Delta502-505, was found to be associated with BP in a Scottish association sample (P=0.007). 17106423 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE These results suggest that GPR50(Delta502-505), or a variant in tight linkage disequilibrium with this polymorphism, is a sex-specific risk factor for susceptibility to bipolar disorder, and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia. 15452587 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET These results suggest that GPR50(Delta502-505), or a variant in tight linkage disequilibrium with this polymorphism, is a sex-specific risk factor for susceptibility to bipolar disorder, and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia. 15452587 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.340 GeneticVariation group LHGDN Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. 15452587 2005
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.320 GeneticVariation disease BEFREE Concerning GPR50, we detected a significant association between ASD and two variations, Delta502-505 and T532A, in affected males, but it did not hold up after Bonferonni correction for multiple testing. 20657642 2010
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.320 Biomarker disease BEFREE In the present study, we have investigated all the genes involved in the melatonin pathway by mutation screening of AA-NAT (arylalkylamine N-acetyltransferase), ASMT, MTNR1A, MTNR1B (melatonin receptor 1A and 1B) and GPR50 (G protein-coupled receptor 50), encoding both synthesis enzymes and the three main receptors of melatonin, in 109 patients with autism spectrum disorders (ASD). 20377855 2010
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.320 Biomarker disease CTD_human Concerning GPR50, we detected a significant association between ASD and two variations, Delta502-505 and T532A, in affected males, but it did not hold up after Bonferonni correction for multiple testing. 20657642 2010
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.310 GeneticVariation disease BEFREE This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. 21565467 2012
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.310 Biomarker disease PSYGENET This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. 21565467 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET These results suggest that GPR50(Delta502-505), or a variant in tight linkage disequilibrium with this polymorphism, is a sex-specific risk factor for susceptibility to bipolar disorder, and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia. 15452587 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease LHGDN These results suggest that GPR50(Delta502-505), or a variant in tight linkage disequilibrium with this polymorphism, is a sex-specific risk factor for susceptibility to bipolar disorder, and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia. 15452587 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease BEFREE These results suggest that GPR50(Delta502-505), or a variant in tight linkage disequilibrium with this polymorphism, is a sex-specific risk factor for susceptibility to bipolar disorder, and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia. 15452587 2005