|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.
|
16339038 |
2005 |
|
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.
|
16339038 |
2005 |
|
Cocaine Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.
|
16339038 |
2005 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Finally, we identify MSK1 as playing a positive role in the control of cell proliferation of both HaCaT keratinocytes and the A431 human epidermoid carcinoma line.
|
16532028 |
2006 |
|
Psoriasis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of pro-inflammatory cytokines.
|
16543895 |
2006 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
This review proposes that MSK1/2 is an optimal target for cancer therapy, based on its fundamental role in transmitting external signals into varied responses involved in cancer development.
|
22250664 |
2012 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
This review proposes that MSK1/2 is an optimal target for cancer therapy, based on its fundamental role in transmitting external signals into varied responses involved in cancer development.
|
22250664 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, MSK1 is an important downstream kinase involved in CS-induced NF-κB activation and chromatin modifications, which have implications in pathogenesis of COPD.
|
22312446 |
2012 |
|
Bone Mineral Density Test
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
|
22504420 |
2012 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
Using the breast cancer cell line T47D, we show that estrogens (E2) and progestins activate MSK1, which forms a complex with the corresponding hormone receptor.
|
23604116 |
2014 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Using the breast cancer cell line T47D, we show that estrogens (E2) and progestins activate MSK1, which forms a complex with the corresponding hormone receptor.
|
23604116 |
2014 |
|
Spinocerebellar Ataxia Type 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
|
23719381 |
2013 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
In both MDA435 wild type (WT) and MDA435 resistant (R) xenografts in nude mice, double silencing of Mcl-1/RPS6KA5 also led to improved inhibition of tumor growth in the absence of chemotherapy.
|
23994345 |
2013 |
|
Bone Mineral Density Test
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
|
24249740 |
2014 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together the data clearly suggest that MSK1 and MSK2 are the major CREB kinases in RAFLS stimulated with LPA and that phosphorylation of CREB1 at Ser-133 downstream of MSKs plays a significant role in chemokine production.
|
24792438 |
2014 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We analyzed 124 CRCs by single-strand conformation polymorphism analysis and DNA sequencing and found 7 (8.9%), 8 (10.1%), and 3 (3.8%) of 79 CRCs with high MSI that harbored IRS1, EIF4B, and RPS6KA5 frameshift mutations, respectively.
|
25776026 |
2015 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the involvement of MSK1 in malignant transformation and cancer development is not well understood.
|
25958199 |
2015 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the involvement of MSK1 in malignant transformation and cancer development is not well understood.
|
25958199 |
2015 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this study, we aimed to explore the role of MSK1 in Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)-promoted carcinogenesis of nasopharyngeal carcinoma (NPC).
|
25958199 |
2015 |
|
Malignant transformation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, the involvement of MSK1 in malignant transformation and cancer development is not well understood.
|
25958199 |
2015 |
|
Nasopharyngeal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, high level of phosphorylated MSK1 was positively correlated with the expression of LMP1 in NPC tissues (r = 0.393, P = 0.002) and cell lines.
|
25958199 |
2015 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Deleting MSK1/2 also inhibits the development of carrageenan-induced inflammatory heat hyperalgesia in mice.
|
28120884 |
2017 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Colocalization and correlating changes in expression of MSK1 and active caspase-3 at neurons and astrocytes indicated that MSK1 downregulation may contribute to SAH-induced apoptosis, validating that MSK1 may be involved in the pathophysiology of the brain cortex subsequent to SAH.
|
28927047 |
2017 |
|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results：In our clinical findings revealed that p38 MAPK, phospho-MSK1, and γ -H2AX were significantly highly expressed in human AK tissue than the normal healthy skin tissue.
|
29298652 |
2018 |
|
Bone Density
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
|
29304378 |
2018 |