Malignant neoplasm of breast
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
As a collaboration of the COVAR clinical trial group (France), and the ENIGMA consortium for investigating breast cancer gene variants, this study evaluated 8 <i>BRCA2</i> variants resulting in complete deletion of exon 3.
|
29707112 |
2018 |
Malignant neoplasm of breast
|
0.340 |
Biomarker
|
disease |
BEFREE |
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia.
|
25857409 |
2014 |
Malignant neoplasm of breast
|
0.340 |
Biomarker
|
disease |
BEFREE |
EBNA-2 and LMP-1 immunohistochemistry were negative in all breast cancer and control specimens.
|
21207256 |
2011 |
Malignant neoplasm of breast
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our group has studied EBV association with breast cancer by using in situ hybridization for detecting nonpolyadenylated EBV RNA (EBERs), along with using protein localization technique of immunohistochemistry, studying the EBV nuclear antigen 1 (EBNA1) and the latent membrane proteins (LMP1 and LMP2A).
|
12218080 |
2002 |
Malignant neoplasm of breast
|
0.340 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, EBV-positive and -negative HL cases express survival, but not death signals of ER stress at similar levels and EBV-LMP1 transfection increases expression of survival signals in HL cell lines.
|
31699300 |
2020 |
Adult Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, EBV-positive and -negative HL cases express survival, but not death signals of ER stress at similar levels and EBV-LMP1 transfection increases expression of survival signals in HL cell lines.
|
31699300 |
2020 |
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, EBV-positive and -negative HL cases express survival, but not death signals of ER stress at similar levels and EBV-LMP1 transfection increases expression of survival signals in HL cell lines.
|
31699300 |
2020 |
Nasopharyngeal carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therapeutically, additional and more specific LMP1 and Capn4 targeted inhibitors could be exploited to treat NPC.
|
31691433 |
2020 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma.
|
30745576 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We reported that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) dysregulates cellular sumoylation processes, contributing to its oncogenic potential in EBV-associated malignancies.
|
31125383 |
2019 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The majority of these SRF/IGF2BP1-enhanced genes, including PDLIM7 and FOXK1, show conserved upregulation with SRF and IGF2BP1 synthesis in cancer.
|
30371874 |
2019 |
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Towards controlled terminology for reporting germline cancer susceptibility variants: an ENIGMA report.
|
30962250 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesize that inhibition of farnesylation with specific small-molecule inhibitors blocks exosome-mediated transfer of prometastatic molecules such as LMP1 during cancer cell-to-cell communications and thereby impedes the process of cancer invasion.
|
29435490 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results point to a second mechanism by which LMP1 dysregulates sumoylation processes and adds EBV-associated lymphomas to the list of malignancies associated with increased SUMO expression.
|
30659232 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As oral cavity is the main location of Epstein-Barr virus (EBV) latency and shedding, and as EBV-encoded latent membrane protein-1 (LMP-1) has a crucial role in cell transformation, association between EBV infection, LMP-1 expression and oral malignancy is of interest.
|
31291930 |
2019 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a HL tissue microarray, 96% of the CD137-positive HL cases stained positive for LMP1.
|
31058559 |
2019 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we report that the bioactivity of antcin H, an analog of the JAK2 inhibitor zhankuic acid A (ZAA), inhibits LMP1-induced JAK/STAT related signaling and induces lymphoma cell line apoptosis.
|
30277103 |
2019 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results point to a second mechanism by which LMP1 dysregulates sumoylation processes and adds EBV-associated lymphomas to the list of malignancies associated with increased SUMO expression.
|
30659232 |
2019 |
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LMP1 DNA and EBER1 RNA correlated with the metastasis of nasopharyngeal carcinoma.
|
31832991 |
2019 |
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma.
|
30745576 |
2019 |
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or LMP1-positive cells can promote cancer progression and metastasis.
|
29435490 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The correlations between these parameters and EBV type (wild-type LMP1 (wt-LMP1) or LMP1 with deletion (del-LMP1)), level of antibodies against EBV, the degree of tumor differentiation, and TNM classification were also investigated.
|
31360295 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Association of Plasma Epstein-Barr Virus LMP1 and EBER1 with Circulating Tumor Cells and the Metastasis of Nasopharyngeal Carcinoma.
|
31832991 |
2019 |