|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of LMP1 can be considered a poor predictor of survival in patients with NHL.
|
28383415 |
2017 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumor cells from approximately 40% of patients with Hodgkin or non-Hodgkin lymphoma express the type II latency Epstein-Barr virus (EBV) antigens latent membrane protein 1 (LMP1) and LMP2, which represent attractive targets for immunotherapy.
|
24344220 |
2014 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To characterize ITAM and CTL motifs of LMP2A and to correlate them with C-terminal variants of LMP1 including the 30-bp deletion variant (LMP1delta), comparative sequence analysis was performed on 76 samples from patients with reactive and malignant lympho-proliferation (infectious mononucleosis, n=21; tonsillar hyperplasia, n=16, chronic lympho-proliferation, n = 9; Hodgkin's disease, n = 8; Non-Hodgkin's lymphoma, n = 5; AIDS-related large-cell lymphoma, n=17).
|
10209951 |
1999 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EBVs detected in lymphocytes in normal gastric mucosa, LCLs in SCID mice and non-Hodgkin's lymphoma were also predominantly affected by type A, wild-type F and LMP-1 gene deletion with few exceptions.
|
10071230 |
1999 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequency and molecular polymorphism of malignancy-associated latent membrane protein 1 (LMP1) variants in human immunodeficiency virus type 1 (HIV-1) infection, 94 B-lymphoblastoid cell lines spontaneously derived from peripheral blood mononuclear cells (PBMC) and 30 PBMC samples at seroconversion and later (mean, 55 months) were analyzed by longitudinal comparative sequence analysis in 8 patients progressing to non-Hodgkin's lymphoma (AIDS-NHL), 7 patients to opportunistic infections, and 2 patients with long-term asymptomatic HIV-1 infection.
|
9841847 |
1999 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumors from both patients with AIDS-associated non-Hodgkin's lymphoma were EBV-positive and expressed LMP1, whereas tumors from all three patients with Burkitt's tumors were positive for EBV but negative for LMP1.
|
9580648 |
1998 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of note, deletions in the LMP-1 gene were detected with similar prevalence values in EBV+ Hodgkin's disease (HD) (13 of 30, 43.3%) and non-Hodgkin's lymphoma (NHL) (2 of 5, 40%) cases from HIV-seronegative patients and in HIV-related, EBV+ NHLs (4 of 7, 57.1%).
|
9057656 |
1997 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Small deletions in the carboxy-terminal domain of LMP1 have been recently described in Hodgkin's disease, nasopharyngeal carcinoma, and non-Hodgkin's lymphoma.
|
8874388 |
1996 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fifty-five cases of non-Hodgkin's lymphoma (NHL) of the upper respiratory tract, comprising 27 sinonasal (SN) and 28 Waldeyer's ring (WR) NHL, were investigated for expression of Epstein-Barr virus (EBV)-encoded EBER transcripts and latent membrane protein-1 (LMP-1) by RNA in-situ hybridization (RISH) and immunohistochemistry, respectively.
|
8778335 |
1996 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LMP-1 was expressed in 12 of 40 (30%) EBER-positive T-NHL and 5 of 25 (20%) EBER-positive B-NHL cases.
|
8562929 |
1996 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differences in EBV association and LMP-1 expression were found between a major group of HIV-associated systemic NHL with blastic cell morphology, including SNCC lymphoma and its variants, and anaplastic cell lymphomas.
|
8394878 |
1993 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transformation-associated EBV latent membrane protein 1 (LMP 1) was detected in 13 (6%) NHL, comprising 4 (4%) high-grade B-cell, 8 (10%) peripheral T-cell, and 1 non-B-cell, non-T-cell lymphomas.
|
1318639 |
1992 |