Epstein-Barr Virus Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As oral cavity is the main location of Epstein-Barr virus (EBV) latency and shedding, and as EBV-encoded latent membrane protein-1 (LMP-1) has a crucial role in cell transformation, association between EBV infection, LMP-1 expression and oral malignancy is of interest.
|
31291930 |
2019 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Fibronectin is regarded as a prognosticator in NPC and its involvement in cell motility has been reported in EBV infection and viral latent membrane protein 1 (LMP1) overexpression NPC cell lines.
|
30551431 |
2019 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these findings suggest that LMP1 modulates different post-translational modifications of SENP2 in order to modulate its biology and identify a third member of the sumoylation machinery that is manipulated by LMP1 during latent EBV infections, which can affect oncogenesis.
|
31266997 |
2019 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The knockout of either LMP1 or LMP2A blocked the eIF4E activation, which is induced either by the EBV infection or by the overexpression of LMP1 or LMP2A.
|
31673282 |
2019 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest new functions of the N terminus and transmembrane domains in LMP1 intra- and extracellular trafficking that are likely downstream of an interaction with CD63.<b>IMPORTANCE</b> EBV infection contributes to the development of cancers, such as nasopharyngeal carcinoma, Burkitt lymphoma, Hodgkin's disease, and posttransplant lymphomas, in immunocompromised or genetically susceptible individuals.
|
29950415 |
2018 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In the context of Epstein-Barr virus (EBV) infection, CD63 is required for the efficient packaging of the major viral oncoprotein latent membrane protein 1 (LMP1) into exosomes and other EV populations and acts as a negative regulator of LMP1 intracellular signaling.
|
29212935 |
2018 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recent evidence has shown that the Epstein-Barr virus (EBV) oncogene LMP1 is not expressed at high levels early after EBV infection of primary B cells, despite its being essential for the long-term outgrowth of immortalized lymphoblastoid cell lines (LCLs).
|
29118124 |
2018 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LMP1 is expressed in EBV-infected germinal center (GC) B cells of immunocompetent individuals, suggesting that it may contribute to persistent EBV infection.
|
30137504 |
2018 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings help to elucidate the still enigmatic link between EBV infection and MS development, suggesting that myelin-reactive antibodies raised as a response toward EBV protein LMP1 are not truly cross-reactive but are primarily caused by epitope spreading.
|
28729867 |
2017 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We show that EBV infection or ectopic expression of the EBV-encoded latent genes (EBNA1, LMP1, and LMP2A) can up-regulate sphingosine kinase 1 (SPHK1), the key enzyme that produces S1P, in NPC cell lines.
|
28240350 |
2017 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, during early infection EBV induces rapid B cell proliferation with low levels of LMP1 and little apoptosis.
|
28425914 |
2017 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunostaining of HL samples (n = 104) showed that expression of MIP-1α, MIP-1β and IL-13 correlated with EBV infection and LMP1 expression.
|
27632954 |
2017 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The mutual regulation between p53 and LMP1 may play an important role in EBV infection and latency and its related cancers.<b>IMPORTANCE</b> The tumor suppressor p53 is a critical cellular protein in response to various stresses and dictates cells for various responses, including apoptosis.
|
28794023 |
2017 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have modeled acute EBV infection of naive and GC B cells in mice through timed expression of LMP1 and LMP2A.
|
27856754 |
2016 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry for EBV related proteins, such as LMP1, is much less sensitive than EBER in situ hybridization, but can help determine latency patterns of EBV infection.
|
25804341 |
2015 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that Epstein Barr virus (EBV) infection of primary human B-cells leads to the down-regulation of DOK1 gene expression via the viral oncoprotein LMP1.
|
24809689 |
2014 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study aimed to investigate the LMP1 expression and EBV infection in relation to clinical outcome and survival in a series of Mexican NPC patients.
|
24606815 |
2014 |
Epstein-Barr Virus Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We therefore investigated the incidence of latent EBV infection in a group of patients with leukemic low-grade B-NHL, as well as the incidence of viral latent membrane protein 1 (LMP1) oncoprotein expression in the same patient group.
|
24261679 |
2014 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our aim was to correlate Fc-γ RIIA polymorphisms, by studying the prevalence of each allele using PCR-RFLPs (polymerase chain reaction-restriction fragment length polymorphisms), with latent Epstein-Barr virus (EBV) infection and the expression of latent membrane protein 1 (LMP1) in 40 patients with leukemic low grade B-cell lymphomas.
|
23270585 |
2013 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Elucidation of the mechanisms involved in LMP1-induced genomic instability in nasopharyngeal epithelial cells will shed lights on the understanding of role of EBV infection in NPC development.
|
22761726 |
2012 |
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, despite documentation of EBV infection by expression of EBNA2 and LMP1, B-CLL cells died after removal of macrophage feeder cells.
|
22160618 |
2012 |
Epstein-Barr Virus Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we investigated the diversity of the EBV genes (EBNA-1 and LMP-1) and the relationship between EBV variants and the clinical phenotypes in diseases associated with EBV infections in Chinese pediatric cases.
|
22236445 |
2012 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
EBV infection was localized by EBV-encoded RNA (EBER) in situ hybridization and by immunohistochemical stains for viral latent proteins LMP1 and LMP2 and for viral lytic proteins BMRF1 and BZLF1.
|
22410851 |
2012 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Tissues from 150 patients were also analyzed for the presence of latent EBV infection using in situ hybridization for EBV-encoded RNA (EBER) and immunohistochemistry for latent membrane protein (LMP1).
|
21143522 |
2011 |
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Epstein-Barr virus (EBV) infection is associated with many human neoplasms, in which EBV-derived latent membrane protein-1 (LMP1) appears to be critical, but its exact oncogenic mechanism remains to be defined.
|
21317926 |
2011 |