PDLIM7, PDZ and LIM domain 7, 9260

N. diseases: 241; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Here, we report that the bioactivity of antcin H, an analog of the JAK2 inhibitor zhankuic acid A (ZAA), inhibits LMP1-induced JAK/STAT related signaling and induces lymphoma cell line apoptosis. 30277103 2019
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) is crucial for B cell transformation and oncogenesis of other EBV-related malignancies, such as nasopharyngeal carcinoma and T/NK lymphoma. 26819314 2016
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE The oncogenic latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is involved in the pathogenesis of human nasopharyngeal carcinoma (NPC) and lymphoma. 23939952 2014
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Because T cells specific for these antigens are present with low frequency and may be rendered anergic by the tumors that express them, we expanded LMP-cytotoxic T lymphocytes (CTLs) from patients with lymphoma using autologous dendritic cells and EBV-transformed B-lymphoblastoid cell lines transduced with an adenoviral vector expressing either LMP2 alone (n = 17) or both LMP2 and ΔLMP1 (n = 33). 24344220 2014
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 PosttranslationalModification disease BEFREE The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1. 24136166 2013
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Using a panel of transfected sublines of the B-lymphoma line BJAB expressing the viral genes associated with latent infection, we show that the EBV nuclear antigens, EBNA-1 and EBNA-3C, and the latent membrane protein 1, LMP-1, independently promote genomic instability, as detected by nonclonal chromosomal aberrations, DNA breaks and phosphorylation of histone H2AX. 19718051 2009
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Although the latent membrane protein-1 (LMP1) of the Epstein-Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. 18566961 2008
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Moreover, IL-10 could induce the expression of LMP-1 in tonsillar B cells infected with the nontransforming, EBNA-2-deficient EBV strain P3HR1 and enhance LMP-1 expression in 2 EBV-positive NK lymphoma lines. 16332968 2006
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE The LMP1-mediated activation of NF-kappaB may contribute to the specific activation of c-Rel and lead to the increased development of lymphoma in the LMP1 transgenic mice. 16247482 2006
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation disease BEFREE The present study revealed a high frequency of EBV association, and a high frequency of 30-bp deletion in the LMP-1 gene in the virus in the present series of lymphoma. 14989738 2004
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE In all four patients, the lymphoma was associated with Epstein-Barr virus infection, detected by EBER in situ hybridization and the latency I phenotype as defined by lack of expression of LMP1. 15104301 2004
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Further, transient Flag-LMP1 expression in a B-lymphoma cell line transduces signals that upregulate TRAF1 levels but does not alter JAK3 levels or activation state. 11739714 2002
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE The AS-oligo to LMP-1 suppressed LMP-1 mRNA and protein expression in two EBV-positive NK cell lymphoma cell lines, as well as in an EBV-transformed B-cell line (CMG-1). 11472349 2001
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation disease BEFREE A comparative sequence analysis of the fingerprint LMP1 region identified in donor lymphocytes and lymphoma was performed. 11502981 2001
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation disease BEFREE Thirty-bp deletion in the LMP-1 carboxy terminal region was demonstrated in the virus-infected lymphoma, but not in the squamous cell carcinomas. 11432667 2001
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE The lymphoma fails to express the EBV transforming proteins EBNA-2 and LMP-1, whereas it expresses EBNA-1 (latency I phenotype). 10673744 2000
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Furthermore, transfection with LMP1 expression vector into a human B lymphoma cell line, Daudi, led to p40 production with nuclear factor (NF)-kappaB activation. 9837745 1998
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Polymerase chain reaction amplification and in situ hybridization revealed that lymphoma and carcinoma cells contained the EBV LMP1 and EBERs genes. 9829857 1998
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE The Epstein-Barr virus latent membrane protein 1 (LMP-1) is essential for virus-induced B cell immortalization and can protect B lymphoma cell lines from apoptosis signals in vitro via induction of cellular Bcl-2 expression. 9367385 1997
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 GeneticVariation disease BEFREE The LMP1 deletion variant and the wild-type sequence were also identified within peripheral blood mononuclear cells of the EBV-seroconverted kidney recipient 20 months after lymphoma therapy. 9381534 1997
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Induction of CD44 expression by the Epstein-Barr virus latent membrane protein LMP1 is associated with lymphoma dissemination. 7537255 1995
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Analysis of EBV gene transfectants of the B lymphoma lines BJAB and BL41 showed that the virus-encoded latent membrane protein-1 (LMP1), which is one of several EBV antigens expressed in group III but not in group I cells, was uniquely able to up-regulate expression both of the Tap proteins and HLA class I. 7774641 1995
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE The EBV latent genes, latent membrane protein 1 (LMP1) and the EBV nuclear antigen 2 (EBNA2), were detected by immunohistochemistry in the Wiskott-Aldrich lymphoma but not in an EBV-positive Burkitt's lymphoma, implying that host immune factors could influence EBV gene expression. 8112728 1994
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Differences in EBV association and LMP-1 expression were found between a major group of HIV-associated systemic NHL with blastic cell morphology, including SNCC lymphoma and its variants, and anaplastic cell lymphomas. 8394878 1993
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE LMP1 effects were also evaluated in the EBV-negative B-lymphoma cell line BL41 and the EBV-positive Burkitt's lymphoma cell line, Daudi (Daudi is deleted for EBNA-2 and does not express LMP). 2157887 1990