|
Classical Hodgkin's Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We describe for the first time the presence of LMP1 protein in EBV-encoded RNA (EBER)-negative follicular dendritic cells (FDCs) of reactive germinal centers (GC) associated with EBV+ cHL.
|
31203443 |
2019 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The EBV genome in virus-associated cHL expresses a limited subset of genes, restricted to the non-coding Epstein-Barr virus-encoded RNAs (EBERs) and viral miRNA, as well as only three virus proteins; the Epstein-Barr virus nuclear antigen-1 (EBNA1), and the two latent membrane proteins, known as LMP1 and LMP2, the latter of which has two isoforms, LMP2A and LMP2B.
|
30149502 |
2018 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LMP1 expression was found in 40% cases of lymphocyte-rich, 66.7% of lymphocyte-depleted, 73.9% of mixed cellularity, 66.7% of nodular sclerosis, and 73.7% of classic Hodgkin lymphoma, NOS.
|
28427406 |
2017 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This pattern is typical of, but is not restricted to, LMP1+EBV-associated cHL.
|
28436953 |
2017 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This scenario is particularly intriguing for the pathogenesis of cHL arising in HIV-infected patients, which, for still obscure reasons, is invariably EBV-associated with LMP-1 expression in HRS cells.
|
27750386 |
2017 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TXN and CXCL9 expression by cHL histiocytes was more frequent in LMP1+, MC and older patients (only for CXCL9).
|
28571489 |
2017 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These methods allowed us to identify the EBV-encoded oncoprotein LMP1 as a key element in the formation of Hodgkin (H-cell) and multinucleated Reed-Sternberg cells (RS-cell), the diagnostic tumor cell of classical Hodgkin's lymphoma (cHL).
|
27873269 |
2017 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to EBV(+) PTLD which expresses the immunodominant EBV latency III EBNA3A/B/C proteins, EBV(+) cHL is restricted to the subdominant EBNA1/LMP1/LMP2 proteins.
|
25731678 |
2015 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All ptHL expressed CD15, CD30 and LMP-1 of EBV; the B-cell markers BOB-1, Oct2, CD79a and CD20 were more commonly expressed in ptHL versus cHL (100%, 86%, 50% and 38% in ptHL compared to 6%, 14%, 10% and 33% in cHL, respectively); all ptHL expressed phosphoinositide 3-kinase (PI3K) versus 81% of cHL; 2/6 (33%) ptHL displayed gains at 9p24 that were similar to cHL (32%).
|
19705967 |
2009 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, the presence of EBV was determined by PCR of the 3' end of the LMP-1 gene and EBNA-3C gene in whole tissue and, consecutively, in isolated cells from 26 cases of cHL: 10 HIV-positive and 16 sporadic cHL cases.
|
17999377 |
2008 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A 30-bp deletion within the LMP-1 gene was in 15/28 (53.6%) EBV-positive cHL cases, and in 41.7% of reactive tonsil samples.
|
17613761 |
2007 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a previous study, we found a high frequency of dual LMP-1 variant (concurrent presence of deleted and nondeleted variants) in cHL from whole-tissue sections.
|
12949802 |
2003 |
|
Classical Hodgkin's Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Direct comparison of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) expression in Hodgkin's and Reed-Sternberg (HRS) cells on conventional full sections with the corresponding duplicate/triplicate tumour cores on the TMA showed a concordance of 100%, indicating that cHL-TMA is a reliable and representative method for evaluating gene expression profiles in situ.
|
12533833 |
2003 |