Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
This meta-analysis demonstrated that gene polymorphism of DEFB1 but not of CD14 might be involved in periodontitis risk.
|
31203191 |
2019 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis.
|
28829191 |
2017 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The expression of TLR2 and CD14 was greatest in the periodontitis group that was classified as severe grade, followed by moderate and mild grades, which suggests a role of TLR2 and CD14 in the pathogenesis of chronic periodontitis.
|
28910171 |
2017 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The CD14/-260 SNP (rs2569190) served as a control, as a recent meta-analysis suggested no relationship between this SNP and periodontitis.
|
26174031 |
2016 |
Periodontitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Further studies are needed to determine if reduced CD14 expression is linked to periodontitis induced by P. gingivalis.
|
25228314 |
2015 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Retrieved studies regarding CD14 -159 C>T and periodontitis susceptibility were put into the final analysis.
|
23517107 |
2013 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis revealed that the 2 common CD14 polymorphisms, C-159T and C-260T, have no association with the likelihood of periodontitis.
|
23582034 |
2013 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD14 is a protein involved in the detection of bacterial lipopolysaccharide (LPS) and has also been associated with periodontitis.
|
23046822 |
2012 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygocity for the C allele of the CD14 (C260T) polymorphism (CC) was associated with a two--fold increased susceptibility to periodontitis (p = 0.04; odds ratio, 2.49; 95% confidence interval, 1.06-6.26).
|
21118416 |
2011 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Soluble CD14 in periodontitis.
|
19318422 |
2009 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate links between genetic polymorphisms of CD14 and TLR4 and risk markers of periodontitis in a multivariate model.
|
19046305 |
2008 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
RGD |
[Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis].
|
17565820 |
2007 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Promoter polymorphisms of the CD14 gene, however, did not influence susceptibility to inflammatory periodontitis in the population cohorts studied.
|
17309585 |
2007 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis adjusted for gender, age, smoking, and prevalence of P. gingivalis and A. actinomycetemcomitans showed an association between the CD14-260T/T genotype and periodontitis (P = 0.004, OR 3.0, 95% CI 1.4-6.9).
|
16246938 |
2005 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the distribution of the CD14 -159C-to-T polymorphism showed no significant difference among males with and without periodontitis (p=0.816).
|
15491315 |
2004 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that CD14 -159C/T polymorphism is not related to the development of periodontitis in a Japanese population, but that, within the periodontitis subjects, expression of the SNP may be related to early disease activity.
|
12885845 |
2003 |