KL, klotho, 9365

N. diseases: 332; N. variants: 20
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 Biomarker disease BEFREE Overexpression or treatment with klotho or KL1 inhibited proliferation of colorectal cancer cells in vitro. 30232408 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE Klotho can suppress the senescent stromal cell-associated triggering of CRC progression by inhibiting the expression of SASP factors including CCL2. 31545552 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 Biomarker disease BEFREE The aim of this study was to examine the role of KL in aerobic glycolysis in colorectal cancer. 29884183 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease BEFREE G-395A polymorphism of Klotho gene could increase the risk of CRC. 26261651 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 Biomarker disease BEFREE In conclusion, we suggest that methylation of some genes (MLH1, PHD3, KLOTHO, p16, and IGFBP7) is important in CRC progression whereas SFRP2 methylation is unlikely to contribute to CRC development in Chinese patients. 24852431 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 PosttranslationalModification disease BEFREE Taken together, our results suggest that KL is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in CRC. 21523445 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease UNIPROT