Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The anti-aging gene klotho is closely related to kidney disease, and an increase in the level of the klotho protein inhibits the progression of various kidney diseases.
|
31273547 |
2019 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Objective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the most important complications of diabetes mellitus (DM), which recently increased due to increased frequency of DM and the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect of hesperidin (HP) on alpha-klotho (α-KL)/ fibroblast growth factor-23 (FGF-23) pathway in rats with diabetes induced by streptozotocin (STZ).
|
30551370 |
2019 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, we discuss the delivery strategy for Klotho in CNI-induced nephropathy.
|
31772699 |
2019 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Diabetic Patients and Its Association with Early Nephropathy.
|
30718148 |
2018 |
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Klotho knockout mice display accelerated aging, and in humans Klotho circulating levels decline with age, renal disease and diabetes.
|
28993191 |
2017 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, our study clarifies how rhein regulation of Klotho expression contributes to its renoprotection and brings new insights into Klotho-targeted strategy for the treatment of kidney diseases of various etiologies.
|
27692562 |
2017 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks.
|
28315683 |
2017 |
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased oxidative DNA damage, accumulation of cell cycle-arrested cells and decreased Klotho expression are assumed to be age-related factors that are reportedly linked to kidney disease.
|
25504369 |
2015 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium.
|
23665422 |
2013 |
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Through independent and combined effects on renal phosphorus and vitamin D metabolism, alterations in FGF23 and Klotho expression are essential for maintaining mineral homeostasis in kidney disease.
|
23611556 |
2013 |
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy.
|
23945089 |
2013 |
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The renal Klotho mRNA and Klotho protein expressions were significantly reduced in the DXR nephropathy group.
|
20606417 |
2010 |