|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of klotho gene polymorphism and the regulation of calcium-phosphate metabolism disorders in patients with end-stage renal disease.
|
30537427 |
2019 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients.
|
29313136 |
2018 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In light of these findings, the main pathophysiological consequence of the downregulation of Klotho observed in acute and chronic renal failure may be the induction of renal FGF23 resistance.
|
29851418 |
2018 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Klotho levels were higher in AKI patients (567.6 ± 294.4 pg/mL, vs. 403.5 ± 152.5 pg/mL, p < 0.01) and females (463.0 ± 202.6 pg/mL vs. 387.6 ± 132.0 pg/mL, p < 0.01) and lower in ESRD patients than in healthy adults and patients with moderate CKD (368.3 ± 99.0 pg/mL vs. 468.1 ± 205.8, p < 0.01 and 368.3 ± 99.0 pg/mL vs. 498.7 ± 221.9, p < 0.01).
|
28157067 |
2017 |
|
Kidney Failure, Chronic
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
The vascular Klotho hypermethylation in radial arteries of patients with end-stage renal disease was described.
|
27766038 |
2016 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
BEFREE |
We studied 40 patients with CKD on conservative treatment (group A), 44 patients with end-stage renal disease (ESRD) on regular hemodialysis (group B), 40 kidney transplant recipients (KTR) (group C) and 40 healthy controls for measuring serum klotho and FGF-23.
|
25766835 |
2015 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Klotho (KL) expression is down-regulated in the renal tissues of chronic kidney disease (CKD) animal models and patients with end-stage renal disease.
|
24224012 |
2013 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sequelae of klotho deficiency are similar to those of end-stage renal disease.
|
23298834 |
2013 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Regarding the significance of cardiovascular disease for the outcome of ESRD patients, we investigated whether genetic variation of klotho was associated with mortality in ESRD patients on hemodialysis.
|
23993164 |
2013 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The klotho gene is predominantly expressed in the kidney and the expression level of klotho RNA was shown to be greatly reduced in the kidneys of chronic renal failure (CRF) patients.
|
16358222 |
2006 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Dietary P(i) restriction induced klotho expression, which enhances the beneficial effect of P(i) restriction in patients with CRF and/or on haemodialysis.
|
12771308 |
2003 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Dietary P(i) restriction induced klotho expression, which enhances the beneficial effect of P(i) restriction in patients with CRF and/or on haemodialysis.
|
12771308 |
2003 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
Recent studies have shown that expression of renal klotho gene is regulated in animal models of metabolic diseases and in humans with chronic renal failure.
|
11967236 |
2002 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure.
|
9731228 |
1998 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure.
|
9731228 |
1998 |