KL, klotho, 9365

N. diseases: 332; N. variants: 20
Disease: Premature aging syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Klotho, a single-pass transmembrane protein associated with premature aging, acts as a tumor suppressor gene by inhibiting insulin/insulin-like growth factor-1 and fibroblast growth factor pathways. 31228703 2019
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function. 29493420 2019
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 AlteredExpression disease BEFREE The klotho gene is a key modulator of aging, with expression deficiency resulting in premature aging, while overexpression extends lifespan and enhances cognition. 28673754 2018
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 AlteredExpression disease BEFREE Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. 28806578 2017
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho-/- mice. 29195509 2017
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Systemic or whole-nephron deletion of Klotho in mice results in renal FGF23 resistance characterized by high 1,25(OH)2D3 and phosphate levels and premature aging. 27292223 2016
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease CTD_human Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. 25550330 2014
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. 23516476 2013
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Klotho null mice are a model for premature aging and exhibit calcific nodules in the aortic valve hinge-region, but do not exhibit leaflet thickening, ECM disorganization, or inflammation. 22248532 2012
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE The klotho gene was originally identified as a putative aging-suppressor gene in mice that extended life span when overexpressed and induced a premature aging syndrome when disrupted. 22660551 2012
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Klotho⁻/⁻ mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1α-hydroxylase, vitamin D receptor, or NaPi cotransporter). 21346722 2011
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. 20482749 2010
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE In contrast, defects in either FGF23 or Klotho are associated with phosphate retention and a premature-aging syndrome. 19626341 2010
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 AlteredExpression disease BEFREE Recent studies using genetically modified mice, such as FGF23-/- and Klotho-/- mice that exhibit altered mineral homeostasis due to a high vitamin D activity showed features of premature aging that include retarded growth, osteoporosis, atherosclerosis, ectopic calcification, immunological deficiency, skin and general organ atrophy, hypogonadism and short lifespan. 19444937 2009
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE klotho-Deficient mice exhibit a syndrome resembling human premature ageing, with multiple pathological phenotypes in tissues including reproductive organs. 16179415 2006
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Recently, klotho has been proposed as a link between cardiovascular diseases and premature aging, but the relationship between KLOTHO genes and cardiovascular risk factors, especially glucose metabolism, in humans is unclear. 16957409 2006
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. 16731043 2006
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. 14528024 2003
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease CTD_human Mutation of the mouse klotho gene leads to a syndrome resembling ageing. 9363890 1997