KL, klotho, 9365

N. diseases: 332; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 GeneticVariation disease BEFREE Association of klotho gene polymorphism and the regulation of calcium-phosphate metabolism disorders in patients with end-stage renal disease. 30537427 2019
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 AlteredExpression disease BEFREE In CKD stage 5, creatinine and cFGF23 levels, as well as the cFGF23/Klotho ratio, were higher (P < 0.01), phosphate and iFGF23 levels were higher (P < 0.05), and Klotho levels were lower (P < 0.01), compared with CKD stage 4. 30689182 2019
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 AlteredExpression disease BEFREE In light of these findings, the main pathophysiological consequence of the downregulation of Klotho observed in acute and chronic renal failure may be the induction of renal FGF23 resistance. 29851418 2018
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 GeneticVariation disease BEFREE We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients. 29313136 2018
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 AlteredExpression disease BEFREE Klotho levels were higher in AKI patients (567.6 ± 294.4 pg/mL, vs. 403.5 ± 152.5 pg/mL, p < 0.01) and females (463.0 ± 202.6 pg/mL vs. 387.6 ± 132.0 pg/mL, p < 0.01) and lower in ESRD patients than in healthy adults and patients with moderate CKD (368.3 ± 99.0 pg/mL vs. 468.1 ± 205.8, p < 0.01 and 368.3 ± 99.0 pg/mL vs. 498.7 ± 221.9, p < 0.01). 28157067 2017
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 PosttranslationalModification disease BEFREE The vascular Klotho hypermethylation in radial arteries of patients with end-stage renal disease was described. 27766038 2016
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker disease BEFREE We studied 40 patients with CKD on conservative treatment (group A), 44 patients with end-stage renal disease (ESRD) on regular hemodialysis (group B), 40 kidney transplant recipients (KTR) (group C) and 40 healthy controls for measuring serum klotho and FGF-23. 25766835 2015
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker disease BEFREE Sequelae of klotho deficiency are similar to those of end-stage renal disease. 23298834 2013
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 GeneticVariation disease BEFREE Regarding the significance of cardiovascular disease for the outcome of ESRD patients, we investigated whether genetic variation of klotho was associated with mortality in ESRD patients on hemodialysis. 23993164 2013
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 AlteredExpression disease BEFREE Klotho (KL) expression is down-regulated in the renal tissues of chronic kidney disease (CKD) animal models and patients with end-stage renal disease. 24224012 2013
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 AlteredExpression disease BEFREE This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure. 9731228 1998
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker disease RGD This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure. 9731228 1998