Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located.
|
11756320 |
2002 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum high-sensitivity C-reactive protein (hsCRP) and the ratio of high-molecular-weight (HMW)/total adiponectin were positively associated with ADS-L in T2D (both P<0.01), but not in T1D.
|
28041985 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied three adiponectin polymorphisms (-11391G > A, +45T > G and +276G > T) in 3086 subjects with type 2 diabetes and high levels of albumin excretion from the diabetes, hypertension, microalbuminuria or proteinuria, cardiovascular events and ramipril (DIABHYCAR) trial.
|
20083470 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes.
|
16352688 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Potential underlying biological mechanisms linking diet quality and T2D risk are an improved lipid profile and reduced systemic inflammation and, with regards to DASH alone, an improved adiponectin profile.
|
28875870 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
ADIPOQ, encoding adiponectin, is a candidate gene for type 2 diabetes (T2D) identified by genome-wide linkage analyses with supporting evidence showing the protein function in sensitizing insulin actions.
|
22046359 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 276G>T polymorphism of the adiponectin (ADIPOQ) gene has been correlated with plasma adiponectin, type 2 diabetes (T2D) and its complications.
|
22222620 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects.
|
31128439 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with T2D have significantly higher levels of A-FABP and lower levels of adiponectin.
|
29717906 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Low serum adiponectin level may precipitate liver steatosis in patients with type 2 diabetes.
|
26042596 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
We analysed baseline adiponectin concentration and CV outcomes in 5213 patients with type 2 diabetes enrolled in the EXAMINE trial of alogliptin vs placebo 15 to 90 days (median 45 days) after ACS.Event rates at 18 months are reported.
|
28195387 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
In recent studies reported that several markers associated with insulin sensitivity in skeletal muscle, Adiponectin and other parameters, such as fatty acid-binding protein (FABP4), have been reported to regulate insulin resistance, but it remains unclear which factor mostly affects insulin resistance in T2DM.
|
28654680 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis was performed to clarify the role of polymorphisms in proximal promoter region of ADIPOQ (rs17360539 and rs266729) in type 2 diabetes.
|
20580771 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, adiponectin plasma concentrations are low in obese subjects, and hypoadiponectinemia is associated with the metabolic syndrome, which is a cluster of insulin resistance, type 2 diabetes mellitus, hypertension, and dyslipidemia.
|
12788102 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The study findings revealed that <i>B. integerrima</i> might be a protective candidate against Type 2 diabetes/insulin resistance through direct insulin-like effect and an increase in adiponectin levels.However, the mechanism of <i>B. integerrima</i> was independent of GLUT4 and PPARγ.
|
29147484 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest that syringin attenuates HFD-induced insulin resistance through the suppressive effect of adiponectin on low-grade inflammation, lipotoxicity, and ER stress, and show syringin as a potential therapeutic agent for prevention and treatment of type 2 diabetes with low risk of adverse effects such as weight gain and dysregulated lipid metabolism.
|
28476623 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Linkage was also present after inclusion of adiponectin concentrations of siblings with type 2 diabetes not treated pharmacologically (total siblings 582, 182 families, 860 sib-pairs: LOD = 3.5).
|
12941784 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin was higher in patients with type 1 diabetes compared to patients with type 2 diabetes, but decreased with treatment with both BIL and glargine.
|
28587667 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
One intron SNP (rs13306519) in LEPR and one 3'UTR SNP (rs1063537) in ADIPOQ demonstrated a significant association with T2DM (P = 0.024 and 0.014 respectively).
|
24414038 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM).
|
28721140 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To clarify the associations between plasma adiponectin levels and ADIPOQ variants with type 2 diabetes incidence in a general Japanese population.
|
28407551 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
|
24825737 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Potentially functional polymorphisms in the peroxisome proliferator-activated receptor-γ (PPAR-γ) and retinoid X receptor-α (RXR-α) genes may alter T2DM risks by increasing the human adiponectin promoter activity in cells.
|
21284483 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Therefore, modulation of adiponectin expression represents a promising target for prevention or treatment of several diseases including insulin resistance and type II diabetes.
|
26610729 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study is to investigate the association between +45T>G and +276G>T polymorphisms of the adiponectin gene and both plasma adiponectin levels and carotid intima-media thickness in patients with diabetes mellitus type 2.
|
25294284 |
2014 |