|
Hyperinsulinism
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These studies 1) definitively demonstrate the presence of severe peripheral and hepatic insulin resistance in the affected subjects; 2) describe a stereotyped pattern of partial lipodystrophy associated with all the features of the metabolic syndrome and nonalcoholic steatohepatitis; 3) document abnormalities in the in vivo function of remaining adipose tissue, including the inability of subcutaneous abdominal adipose tissue to trap and store free fatty acids postprandially and the presence of very low circulating levels of adiponectin; 4) document the presence of severe hyperinsulinemia in prepubertal carriers of the proline-467-leucine (P467L) PPAR-gamma mutation; 5) provide the first direct evidence of cellular resistance to PPAR-gamma agonists in mononuclear cells derived from the patients; and 6) report on the metabolic response to thiazolidinedione therapy in two affected subjects.
|
12663460 |
2003 |
|
Hyperinsulinism
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analyses showed that factors associated with breast cancer were BMI [OR (95% CI) =2.8 (1.4-5.5), P=0.004]; high levels of adiponectin [5.1 (2.2-11.5), P<0.001); hyperinsulinaemia [1.1 (1.0-1.1), P=0.01], leptin [3.1 (1.7-5.7), P<0.0001], estradiol [2.5 (1.3-4.7), P=0.005] and testosterone [1.3 (1.03-1.7), P=0.03].
|
22664497 |
2012 |
|
Hyperinsulinism
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The association of the functional promoter polymorphism rs266729 with lower serum adiponectin and increased insulin resistance in diverse ethnic groups may suggest a causal relationship between adiponectin level and insulin resistance.
|
23826141 |
2013 |
|
Hyperinsulinism
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resistance training had no effect on the plasma adiponectin response to hyperinsulinemia.
|
29412474 |
2018 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adiponectin, an adipose tissue-derived hormone, exhibits anti-inflammatory properties and has various biological functions, such as increasing insulin sensitivity, reducing hypertension, and suppressing atherosclerosis, liver fibrosis, and tumor growth.
|
16952554 |
2006 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Expression of AdipoR isoforms can be regulated by hyperinsulinaemia and hyperglycaemia with the consequence of increased sensitivity or resistance to specific forms of adiponectin.
|
17052201 |
2006 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
RGD |
Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
|
16414018 |
2006 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, high adiponectin predicts increased insulin sensitivity.
|
12540592 |
2003 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
These changes were associated with reductions in NO and adiponectin bioavailability, and rescued by exogenous adiponectin or hyperinsulinemia.
|
30006585 |
2019 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the chronic experiment, nutraceuticals did not alter body weight or glycemic control, but improved fed hyperinsulinemia (mean difference = 30.80 mU/L, <i>p</i> = 0.044) and homeostatic model assessment-insulin resistance (HOMA-IR) (mean difference = 15.29, <i>p</i> = 0.033), and plasma adiponectin levels (mean difference = -0.99 µg/mL, <i>p</i> = 0.048).
|
29271886 |
2017 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
The following biomarkers were assessed in plasma samples donated by chronic disease-free women (1990) and men (1994): C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α receptor 2 (TNFαR2) and adiponectin for inflammation; estrone and estradiol for hormonal response in women, C-peptide for hyperinsulinemia; and triglycerides/high density lipoprotein-cholesterol (TG/HDL) ratio for insulin resistance.
|
27798951 |
2017 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adiponectin stimulates fatty acids oxidation, decreases plasma triglycerides, and improves glucose metabolism by increasing insulin sensitivity.
|
12601307 |
2003 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity.
|
22996660 |
2012 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Low plasma adiponectin concentration independently predicted future abdominal visceral fat accumulation and increased insulin resistance in Japanese Americans.
|
29029184 |
2017 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.
|
29494595 |
2018 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
A low serum level of high molecular weight adiponectin was associated with an increased insulin level and resistance in the women exposed to SHS.
|
30356972 |
2018 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, adiponectin and omentin from subcutaneous fat displayed correlations with decreased obesity and increased insulin sensitivity while visfatin showed an association with serum PYY and weight gain.
|
25453978 |
2014 |
|
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
However following dexamethasone which increased insulin resistance, the relationship between adiponectin and the biochemical measures was lost.
|
18363889 |
2008 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Severe obesity is associated with suppressed expression of both ApN and its receptors in both SAT and VAT, the expression levels in VAT are specifically linked with hyperinsulinemia and dyslipidemia.
|
17607322 |
2007 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin and decreased adiponectin levels along with endothelial dysfunction are present in normotensive subjects with FT. IR and hypoadiponectinemia are interrelated, but only hyperinsulinemia has an independent adverse influence on endothelial function.
|
23822941 |
2013 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Insulin increased adiponectin expression specifically in the omental tissue (P = 0.011).
|
18208577 |
2008 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, these rats showed hyperinsulinemia, decreased insulin sensitivity, increased insulin resistance, down-regulated mRNA levels of adiponectin receptors in inguinal white adipose tissue (Adipor1 and Adipor2) and soleus muscle (Adipor2), and decreased levels of phosphorylated AMPK, the downstream post-receptor target of adiponectin, in the soleus muscle.
|
28974704 |
2017 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expressions of both resistin and adiponectin in s.c. adipose tissue are stimulated by acute hyperinsulinaemia, whereas losartan attenuates their insulin-stimulated expressions.
|
17893258 |
2007 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin as well as HOMA-IR levels and decreased adiponectin levels were found in VPA treated subjects when compared to the newly diagnosed patients.
|
29906708 |
2018 |