Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Plasma adiponectin levels in overweight and obese Asians.
|
12429873 |
2002 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
LHGDN |
Decreased plasma adiponectin concentration in patients with essential hypertension.
|
12517687 |
2003 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
CTD_human |
Adiponectin-KO mice showed obesity, hyperglycemia, and hypertension compared with WT mice after 4 weeks on an atherogenic diet.
|
12860835 |
2003 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension.
|
15123570 |
2004 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Growing evidence suggests that concentration of the adipocytokines leptin and adiponectin may be affected by risk of hypertension during pregnancy.
|
16785148 |
2006 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population.
|
16944773 |
2006 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
LHGDN |
Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension.
|
17452504 |
2007 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Plasma adiponectin, T94G gene polymorphism and PAI-1 in patients with and without hypertension.
|
16741355 |
2007 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction.
|
18506375 |
2008 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To date, there have been no studies supporting the relationship between epicardial adipose tissue (EAT) expression of adiponectin and HT.
|
18650840 |
2008 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Logistic regression analysis after adjustment for age, sex, adiponectin and S447X polymorphism demonstrated that LPL mass was inversely associated with CHD in men and both genders (p=0.02), with hypertension confined to women (p=0.04) and with MS likelihood in both genders combined and women [odds ratio 1.51 (95% CI 1.14-2.00) for halving the likelihood].
|
19191728 |
2009 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Low plasma adiponectin concentrations are associated with myocardial infarction in individuals below the age of 60, and this remains significant after adjustment for history of hypertension, HDL cholesterol, smoking and BMI.
|
20528971 |
2010 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The risk of high blood pressure (≥160/110 mm Hg) and of high serum adiponectin in T-allele carriers at +276G/T in the severe preeclamptic group were 5.345 and 5.818 times higher, respectively, compared with GG patients.
|
20664545 |
2010 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
No significant sex interaction was found for the associations of SNPs with hypertension and adiponectin level.
|
20516205 |
2010 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
No association of ADIPOQ gene with HTN alone or MetS without HTN was observed.
|
21637762 |
2011 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This and other single-nucleotide polymorphisms have been associated with hypertension and adiponectin level in separate studies.
|
21872196 |
2011 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Infusion of Ang II increased blood pressure (p < 0.001) but decreased vascular relaxation in response to acetylcholine, endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (peNOS) levels, and renal and plasma levels of adiponectin (p < 0.05); in contrast, plasma tumor necrosis factor-α and monocyte chemoattractant protein-1 levels increased.
|
20836698 |
2011 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension.
|
21150884 |
2011 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Low levels of serum adiponectin are now appreciated as a risk factor in a variety of cardiovascular diseases including coronary artery disease and restenosis, type 2 diabetes mellitus, and hypertension.
|
23017720 |
2012 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, a meta-analysis was performed to assess the associations of ADIPOQ polymorphisms with hypertension risk among the Chinese.
|
22714914 |
2012 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, adiponectin receptors may provide a potential therapeutic target of agents activating their beneficial action.American Journal of Hypertension 2012; doi:10.1038/ajh.2012.42.
|
22534793 |
2012 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, high circulating levels of adiponectin were found to be associated with hypertension only in type 2 diabetic female patients which might indicate a gender preference.
|
23057719 |
2013 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs.
|
23845780 |
2013 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin plays an important role in the development of hypertension, atherosclerosis, and cardiomyocyte hypertrophy, but very little was known about the influence of serum adiponectin or the adiponectin gene polymorphism on myocardial fibrosis.
|
23897791 |
2013 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Clinical observation showed that lower plasma adiponectin concentration is significantly associated with hypertension.
|
23478100 |
2013 |