Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease.
Genetically predicted coffee consumption was not associated with T2DM (odds ratio (OR) 1.02, 95% confidence interval (CI) 0.76 to 1.36), depression (0.89, 95% CI 0.66 to 1.21), Alzheimer's disease (1.17, 95% CI 0.96 to 1.43), IHD (0.96, 95% CI 0.80 to 1.14), lipids, glycemic traits, adiposity or adiponectin.
Instead HOMA-IR and adiponectin appeared independently associated both to de novo IHD (OR 9.6*10<sup>13</sup>; 95% CI 3.026-3.08*10<sup>27</sup>; p = 0.042 and OR 0.206; 95% CI 0.053-0.796; p = 0.000, respectively) and overall new PCI (OR 1.5*10<sup>11</sup>; 95% CI 2.593-8.68*10<sup>21</sup>; p = 0.042 and OR 0.206; 95% CI 0.053-0.796; p = 0.000, respectively).