Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 GeneticVariation disease BEFREE Whole-cell patch-clamp recordings in brain slices revealed that intrinsic excitability of DG granule neurons was enhanced by adiponectin deficiency and suppressed after treatment with the adiponectin mimetic AdipoRon, which were associated with increased input resistance and hyperpolarized resting membrane potential, respectively. 27137743 2017
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 AlteredExpression disease BEFREE In this study, in order to determine whether adiponectin affects tumor growth and tumor induced vascularization, we implanted B16F10 melanoma and Lewis Lung Carcinoma cells subcutaneously into adiponectin knockout and wild-type control mice, and found that adiponectin deficiency markedly promoted the growth of both tumors. 20700533 2010
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 AlteredExpression disease BEFREE Adiponectin overexpression also promoted apoptotic cell clearance and reduced features of autoimmunity in lpr mice whereas adiponectin deficiency in lpr mice led to a further reduction in apoptotic cell clearance, which was accompanied by exacerbated systemic inflammation. 17256056 2007
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 Biomarker disease BEFREE The present study provides evidence that adiponectin is a protective regulator in the development and progression of BPH and that adiponectin deficiency causally links BPH with obesity. 28256562 2017
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 Biomarker disease BEFREE Exogenous recombinant adiponectin specifically dampened airway chitin-mediated eosinophil recruitment, while adiponectin deficiency resulted in increased airway eosinophils. 31134096 2019
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 Biomarker disease BEFREE This study aims to develop adiponectin secreting genetically modified MSCs (GM-MSCs) as a potent strategic tool to complement endogenous adiponectin for the treatment of adiponectin deficiency diseases. 28606849 2017
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 Biomarker disease BEFREE To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (<i>Adipoq<sup>-/-</sup></i> ) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. 28073830 2017
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 Biomarker disease CTD_human